1、mucous membrane lining the eyelidscornea,conjunctiva and tear film CONJUNCTIVA CORNEA LIMBUS STEMCELLS TRANSIENT AMPLIFYINGCELLS POSTMITOTICCELLS TERMINALLYDIFFERENTIATEDCELLS Reproductive activity infinite finite Fissionability low highDifferentiation potency concentric movementconcentric movement,
2、corneal vascularization,healing delay抑制炎症反应促进上皮化抗新生血管形成抗纤维化缓解疼痛角膜缘干细胞体外培养的龛环境口腔黏膜上皮口腔黏膜上皮羊膜羊膜acA.对照组B.实验组2W4WacThe structure of the tear-filmLipid layer produced bymeibomian glandsAqueous layer by accessory lacrimal glandsMucin layerby goblet cellsLacrimal glandSecretomotor impulseAfford ocular surf
3、ace tearNervous of ocularSurface excitationvirgin forest desert and gobiThe influence of organic evolution and human modern civilizationMarine life Amphibia Terrestrial animal Human beingShanxiZhejiangBeijingLanzhouWorking face the screenVisual function burden increasedAbout 50%female who is 35-50 y
4、ears old in U.S.A.suffering from the dry eye symptoms SchirmerII and SchirmerII and decrease,osmotic pressure of tear decrease,osmotic pressure of tear increase,and all will increase,and all will recover in 69 months.NI-BUT正常（正常（R1R1）干眼症（）干眼症（R2R2）正常为正常为0.50.51.0mm1.0mm 0.35 mm 0.35 mm是诊断为干眼是诊断为干眼No
5、n-Invasive,convenient,high specificityPatel Ophthalmic Physiol 1998：471normalDry eye表面规则指数表面规则指数0.63睁眼睁眼10S后表面规则指数后表面规则指数0.84Normal 表面规则指数表面规则指数1.4睁眼睁眼10S后表面规则指数后表面规则指数6.28Dry eyeGoto Am J Ophthalmol 2002:181Dry eyenormalAutologous transplantation of free submandibularlSodium Hyaluronate Eye DropsSo
6、dium Hyaluronate Eye DropsnPseudomonas aeruginosa corneal ulcer:drug discontinuance with cautionnBed isolation to inpatients Fungal keratitisnThick hypopyonnCorneal scraping:hyphae or sporesFungal keratitisFungal keratitisFungal keratitisFungal keratitisFungus in general尖孢镰刀菌尖孢镰刀菌芽生菌芽生菌黄曲霉黄曲霉Chysosp
7、orium sp.Fungus microscopic characteristics茄病镰刀菌茄病镰刀菌芽生菌芽生菌弯孢霉弯孢霉黄曲霉黄曲霉HRTFungal keratitisFungal keratitisnGlucocorticoid disabledCorneal transplantation indicationCCorneal transplantation indicationCorneal transplantation indicationkeratitiskeratitiskeratitiskeratitiskeratitis离体组织学检查离体组织学检查 (光学显微镜光
8、学显微镜)活体检查活体检查 (NIDEK)(NIDEK)keratitis(HRT 3)keratitisHerpes simplex keratitisHerpes simplex virus infectionOften by HSV-I HSV-II by chanceHerpes simplex keratitisnAntiviral drugsviral keratitisNecrotic interstitial keratitisviral keratitisAutoimmune interstitial keratitisviral keratitisviral keratitisviral keratitis
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