1、l 肿瘤新生血管生成和血液动力学改变Forner A,et al.Hepatology 2008Sangiovanni A,et al.Gut 2010l Bartolozzi C,et al.Eur Radiol 2007l Bartolozzi C.2010 ECRl Choi BI.2011 ESGAR-敏感的信号捕捉和较好的软组织分辨力-脂肪变性的探测更敏感细胞密度、数目及排列的改变、纤维组织平衡灌注的影响普通钆剂；对富血供病变更敏感肝细胞对比剂：肝细胞的肝胆功能及胆管发育/排泌含铁超顺磁性对比剂：枯否细胞数量及其吞噬功能铁沉积、微出血、静脉血管反映代谢产物变化-弥漫肝病（肝纤维化）、
2、肝结节-弥漫肝病（肝纤维化）科研 科研T2WT1Wl 代谢物异常l 结构改变T2WT1WT2W压脂压脂平扫T2*SPIOSPIO+GaOut phaseIn phaseFat fraction mapF=(Sip-Sop)/2(Sip)DN 伴脂肪变性MR-DWI,Hepatobiliary Phase&SPIO ImagingMR-DWI,Hepatobiliary Phase&SPIO ImagingMR-DWI,Hepatobiliary Phase&SPIO ImagingT2T1APDWI20mT2T1APDWI20mMR-DWI,Hepatobiliary Phase&SPIO I
3、magingMR-DWI,Hepatobiliary Phase&SPIO ImagingT1-APT1-PVP20m低分化HCCLarge 再生结节Courtesy of Dr.JM Leel Adenoma(HNF1-inactivated)l FNHMR-DWI,Hepatobiliary Phase&SPIO ImagingJin Chung,et al.Magnetic Resonance Imaging 29(2011)1235MR-DWI,Hepatobiliary Phase&SPIO Imagingl 动脉期强化l 结节大小l 延迟期廓清l 假包膜l 结节生长l 肝胆期表现 低信号l DWI 高信号，低ADC值l T2高信号，T1低信号l 脂肪变性l.组织病理层面特征细胞/分子病理层面特征KUDO M.J Gastroenterol 2009,44:112118
