1、Since You Asked-Bisphenol A(BPA)Questions and Answers about Bisphenol A by GC0902BPAWhat is BPAWhere is BPA foundHow does BPA get into the bodyDetermination of BPATo prevent exposure to BPAsince you asked BPAU.S.A2009/3EU2011/3/1Canada2008/5CN2011/6/1What is bisphenol A?Bisphenol A(BPA)is a chemical
2、 produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins.1891 This compound is synthesized by the condensation of acetone(hence the suffix A in the name)with two equivalents of phenol.The reaction is catalyzed by a strong acid.Industrially,a large
3、excess of phenol is used to ensure full condensation;the product mixture of the cumene process(acetone and phenol)may also be used as starting material:phenol.Bisphenol A phenol.Bisphenol AWhere is BPA found?food and drink packaging,e.g.,water and infant bottles,compact discs,impact-resistant safety
4、 equipment,and medical devices.metal products such as food cans,bottle tops,and water supply pipes.dental sealants and compositesHow does BPA get into the body?The primary source of exposure to BPA for most people is through the diet.While air,dust,and water are other possible sources of exposure,BP
5、A in food and beverages accounts for the majority of daily human exposure.Bisphenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware,food storage containers,water bottles,and baby bottles.The degree to
6、which BPA leaches from polycarbonate bottles into liquid may depend more on the temperature of the liquid or bottle,than the age of the container.Determination of BPA in food simulantsReagentsApparatusProcedureExpression of resultsReagentsBPAn-HexaneMethanolDeionized water Extraction solvent,methano
7、l/water=1:1Mobile phase for HPLC methanol/water=70:30Stock solution of BPA in methanol at a defined concentration of approximately 0.38mg/mlApparatus High performance liquid chromatography HPLC column Mechanical shaker(vortex)Micro syringes Test tubesProcedureHPLC analysis Calibration Execution of d
8、etermination HPLC interferences Expression of results 1.Graphical determinationExpression of results 2.Calculation from the regression parameters.If the regression line equation is:y=(ax)+bthe peak area of BPAthe slope of the regression line in milligrams per kilogramthe concentration of BPA in the
9、food simulant in milligrams per kilogramthe intercept of the regression line the concentration of BPA in the food stimulant in given by:C=(y-b)/aIf I am concerned,what can I do to prevent exposure to BPA?Plastic containers have recycle codes on the bottom.Reduce your use of canned foods.When possible,opt for glass,porcelain or stainless steel containers,particularly for hot food or liquids.Use baby bottles that are BPA free.Dont microwave polycarbonate plastic food containers.Identification in plastics
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