T淋巴细胞医学宣教课件.ppt

1、Ins of immunopharmo&immunotha1The Journal of ImmunologyThe Journal of ImmunologyT T淋巴细胞淋巴细胞Ins of immunopharmo&immunotha2The Journal of ImmunologyThe Journal of Immunology第二节第二节 T T淋巴细胞的表面分子及其作用淋巴细胞的表面分子及其作用Ins of immunopharmo&immunotha3The Journal of ImmunologyThe Journal of ImmunologyIns of immuno

2、pharmo&immunotha4The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha5The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha6The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha7The Journal of ImmunologyThe Journal of Imm

3、unologyIns of immunopharmo&immunotha8The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha9The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha10The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha11The Journal of Immuno

4、logyThe Journal of ImmunologyIns of immunopharmo&immunotha12The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha13The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha14The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunoth

5、a15The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha16The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha17The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha18The Journal of ImmunologyThe Journal of ImmunologyIns

6、of immunopharmo&immunotha19The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha20The Journal of ImmunologyThe Journal of Immunology 第一节第一节 T T细胞的分化发育细胞的分化发育Ins of immunopharmo&immunotha21The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha22The J

7、ournal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha23The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha24The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha25The Journal of ImmunologyThe Journal of ImmunologyIns of immun

8、opharmo&immunotha26The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha27The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha28The Journal of ImmunologyThe Journal of Immunology第三节第三节 T T淋巴细胞的亚群淋巴细胞的亚群Ins of immunopharmo&immunotha29The Journal of

9、 ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha30The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha31The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha32The Journal of ImmunologyThe Journal of Immunology特征特征TCR多样性多少分布外周血60%-

10、70%5%-15%组织外周淋巴组织皮肤表皮和粘膜上皮表型CD2CD3100%100%CD4+CD8+60%-65%1%CD4-CD8+30%-35%20%-50%CD4-CD8-5%50%识别抗原8-17个氨基酸组成的肽 HSP，脂类，多糖提呈抗原经典MHC分子MHC I类样分子MHC限制性有无辅助细胞Th细胞无（？）杀伤细胞CTL细胞gdT杀伤活性Ins of immunopharmo&immunotha33The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha34The Journal

11、of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha35The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha36The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha37The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo

12、&immunotha38The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha39The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha40The Journal of ImmunologyThe Journal of Immunology第四节第四节 T T淋巴细胞的功能淋巴细胞的功能Ins of immunopharmo&immunotha41The Journal of Immuno

13、logyThe Journal of ImmunologyIns of immunopharmo&immunotha42The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha43The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha44The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunoth

14、a45The Journal of ImmunologyThe Journal of ImmunologyIns of immunopharmo&immunotha46The Journal of ImmunologyThe Journal of ImmunologyIMMUNOLOGYIMMUNOLOGYIns of immunology思考：思考：1.理解理解T细胞在胸腺中分化发育发生的主要事件及其机细胞在胸腺中分化发育发生的主要事件及其机制。制。2.理解与抗原识别相关的理解与抗原识别相关的T细胞表面分子及其功能的对细胞表面分子及其功能的对应关系。应关系。3.掌握掌握T细胞的功能分型及其功能特点。细胞的功能分型及其功能特点。