1、泌尿系统疾病英文,(1)glomerular minor 1esion (2)focal and segmental glomerular change A.focalnephritis B.focal and segmental glomerulosclerosis (3)diffuse glomerulonephritis A.membranous glomerulonephritis (membranous nephropathy)B.proliferative glomerulonephritis a.mesangial proliferative glomerulonephritis
2、 b.endocapillaryproliferative glomerulonephritis c.mesangiocapillary glomerulonephritis (membranoproliferative glomerulonephritis type I and III)d.crescentic glomerulonephritis e.IgA nephropathy C.sclerosing glomerulonephritis (4)unclassified glomerulonephritis (1)1upus nephritis (2)nephritis of Hen
3、och-Schonlein purpura (3)anti-GBM nephritis,Goodpasture syndrome YY YYYYYYYYGBM-autoantigenfibrin platelet.Acute diffuse proliferative GN called also:endocapillary proliferative GN,endothelial-mesangial proliferative glomerulonephritis post-streptococcus GN ,parasite parasite glomerule enlarge,and f
4、illed with cells(mesangial and endothelia cell),capillary lumen narrowed.parietal epithelium without hyperplasiaCamel peak-like Urine alteraion:milliliter,(renin)3.Reprognosis depend to the number of crescent:50%crescent prognosis well50-80%crescent progress slowly 80-90%death(2)Turn to chronic scle
5、rosing GN,Slide 21.29the proliferation of“basement membrane substanceimmune complex deposit ,highhighhighlowSlide 21.37Mesangial cell and mesangial matrix proliferate very much and insert into the capillary wall,the BM show splitting(two layer).Railway-like Slide 21.30Slide 21.32highhighhighlowInjor
6、y of glomerular capillary wallFiltration of albuminplasma proteinHypoalbuminemiaplasma colloid osmotic pressure Water into tissueedemablood volume glomerular filtration rate Aldosterone and antidiuretic hormone Sodium and water retentionaggravatingHigh proteinuriaHypoalbuminemiaHypoalbuminemiaLipopr
7、oteins synthesis in liverdisorders of lipid granule transportation in blood and breakdown of peripheral lipid proteins causes:Fobrosis and hyelinzed of glomerulireninVII IgA NeSlide 21.39IgA depositionSclerosis of some glomeruli;portions of capillary involved.ratio,renal stroma develop suppurative i
8、nflammation,tubules filled with liquor pus.renal stroma develop suppurative inflammation,forming,tubules filled with .Acute pyelonephritis:size and shape irregular abscesseson surfaceAcute pyelonephritis Abscesses some abscesses are long shaped according to the structurefever,aching pain in the wais
9、t,irritation sign of bladder:urinary frequency,urgency,odynuria.Slide 21.55Cortex become thin,pelvis is dilated,the mucosa is coarse“Large scar concave atrophy of the kidney”Slide 21.56“Large scar concave atrophy of the kidney”(thyroid tissue like)(thyroid tissue like)Proliferation of transitional e
10、pithelium Slide 21.72Soft,calcify Slide 21.73 ,parathyroid hormone,renin,gonad stimulating hormone,adrenal cortex(ACH)hormone,erythropoietin(EPO).B.Pathology.Grossly:Usually it is a papillary tumor with slender or broad pedicle,sometime it shows cauliflower-like or polypous,sometime it is flat.a papillary tumor with slender or broad pedicle,show cauliflower-like or polypous.LM:It may be divided three grade:1.grade:Low malignancy,the papilla is covered by orderly transitional epithelium.(510 layers).Hematuria without pain.Bladder irritation.Urinary tract obstruction
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