糖皮质激素中英对照培训课件.ppt

1、糖皮质激素中英对照糖皮质激素中英对照糖皮质激素中英对照2糖皮质激素中英对照3糖皮质激素中英对照4肾上腺皮质激素基本结构及维持生理功能必需基团肾上腺皮质激素基本结构及维持生理功能必需基团糖皮质激素中英对照5C C1717上无上无-OH-OH，C C1111上无上无O O或有或有O O与与C C1818相联相联糖皮质激素中英对照6C C1717上有上有-OH-OH，C C1111上有上有=O=O或或-OH-OH；C C1-21-2的为双键抗的为双键抗炎作用增强、水盐代谢作用减弱炎作用增强、水盐代谢作用减弱糖皮质激素中英对照7C C9 9引入引入-F-F，C C1616引入引入-CH-CH3 3或或

2、-OH-OH则抗炎作用更强、则抗炎作用更强、水盐代谢作用更弱水盐代谢作用更弱糖皮质激素中英对照8糖皮质激素中英对照9水电解质代谢水电解质代谢l潴钠排钾；利尿；低血钙潴钠排钾；利尿；低血钙核酸代谢核酸代谢l诱导特殊诱导特殊mRNAmRNA合成合成 -转转录一种抑制细胞膜转运功能录一种抑制细胞膜转运功能的蛋白质的蛋白质 -抑制细胞对葡抑制细胞对葡萄糖、氨基酸等物质的摄取萄糖、氨基酸等物质的摄取糖皮质激素中英对照10糖皮质激素中英对照11糖皮质激素中英对照12糖皮质激素中英对照13糖皮质激素中英对照14糖皮质激素中英对照15糖皮质激素中英对照16糖皮质激素中英对照17激素与胞浆内受体结合，促其释出激

3、素与胞浆内受体结合，促其释出hsp90hsp90、hsp70hsp70和和IPIP，受体进入细胞核与靶基因的，受体进入细胞核与靶基因的GREGRE结合，调节基因表达，最后产生生物效应结合，调节基因表达，最后产生生物效应。糖皮质激素中英对照18糖皮质激素中英对照19糖皮质激素中英对照20糖皮质激素中英对照21糖皮质激素中英对照22糖皮质激素中英对照23糖皮质激素中英对照24糖皮质激素中英对照25糖皮质激素中英对照26糖皮质激素中英对照27糖皮质激素中英对照28糖皮质激素中英对照29糖皮质激素中英对照30糖皮质激素中英对照31糖皮质激素中英对照32糖皮质激素中英对照33糖皮质激素中英对照34糖皮质

4、激素中英对照36糖皮质激素中英对照37糖皮质激素中英对照38糖皮质激素中英对照39糖皮质激素中英对照40糖皮质激素中英对照41糖皮质激素中英对照42糖皮质激素中英对照43糖皮质激素中英对照44 Adrenocortical hormones The steroid compounds produced by the adrenal contex are called adrenocorticosteroids,and they can be divided into two major groups depending on their relative metabolic(glucocort

5、icoid)versus electrolyte-regulating(mineralocorticoid)activity 糖皮质激素中英对照45HYDROCORTISONE(CORTISOL)is the main glucocorticoid produced by the adrenal glands The pharmacological actions of steroid are an extension of their physiological effects Almost every cell in the body will respond to these compo

6、unds 糖皮质激素中英对照46After entering the cell and binding to the receptor,the receptor-hormone complex is transported into the nucleus where it acts as a transcription factor for specific genes All of the steroids(including the sex steroids)bind to intracellular receptors in target tissues糖皮质激素中英对照47Gluco

7、corticoidsGlucocorticoids receptors are found in virtually every cell in the body Glucocorticoids promote metabolism of protein and gluconeogenesis.The glucocorticoids stimulate formation of glucose and cause breakdown of protein into amino acids糖皮质激素中英对照48Glucocorticoids inhibit inflammatory and im

8、munological responses.This is the basis of their therapeutic use and the reason why patients on glucocorticoids have increased susceptibility to infections All steps in the inflammatory process are blocked糖皮质激素中英对照49Glucocorticoids are used for replacement therapy in patients with malfunctioning adrenal glands.But the most important use of glucocorticoids is to reduce inflammation or block immunological and allergic responses The complication of glucocorticoids therapy appear in all organ systems 糖皮质激素中英对照50