1、睡眠的生理学意义 消除疲劳、恢复体力 保护大脑、恢复精力提高机体的免疫力对儿童,睡眠有促进生长发育的特殊意义Nelson 儿科学,17版,2007;99Nelson 儿科学,17版,2007;99Nelson 儿科学,17版,2007;99 WATERS K A,Am J Med Genet,1995,59(4):460-466.Hsueh-yu L,Chang Gung Med J,2009;32:24757AMERICAN THORACIC SOCIETY.Am J Respir Crit Care Med,1996,153(2):866-878.AMERICAN THORACIC SOC
2、IETY.Am J Respir Crit Care Med,1996,153(2):866-878.OSAS in children is a disorder of breathing during sleepcharacterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction(obstructive apnea)that disrupts normal ventilation during sleep and normal sleep patterns.It
3、 is associated with symptoms including habitual(nightly)snoring,sleep difficulties,and/or daytime neurobehavioral problems.Complications may include growth abnormalities,neurologic disorders,and cor pulmonale,especially in severe cases.Various risk factors have beenidentified and are defined.Carolyn
4、 E I-L,AJRCCM,2007;175:436441OSAS对机体的影响Oscar S C,Proc Am Thorac Soc,2008;5:274282Oscar S C,Proc Am Thorac Soc,2008;5:274282Kahn A,Sleep,1993;16:409413Crouzon syndromeOscar S C,Proc Am Thorac Soc,2008;5:274282Oscar S C,Proc Am Thorac Soc,2008;5:274282蒙逖航,医学综述,2008;14(20):31413143OSA引起心血管事件的细胞学机制Athan
5、asios G,Chest,2008;134:324331A,adenoid;N,nasopharyngeal measurement;P,pharyngeal measurement;T,tonsil.T/P 0.479提示中重度OSA。A/N 0.74以上A M Li,Arch Dis Child 2002;87:156159 Liner LH,Curr Opin Pediatr,2006,18(3):272-276.S L Verhulst,Arch Dis Child 2006;91:233237Marcus CL,Pediatr Pulmonol,1992;13:1621Biban
6、P,Pediatrics,1993;92:461463Brouillette R,J Pediatr.1984;105:1014William WH,Pediatrics Current diagnosis&Treatment,19th ed,2009;467McColley S,Arch Otolaryngol Head Neck Surg,1992;118(9):940943Goldberg S,Pediatr Pulmonol,2005;40(3):205210Rosen GM,Pediatrics,1994;93(5):784788Gorur K,Int J Pediatr Otorh
7、inolaryngol,2001,59(1):41-46.Basha S,Laryngoscope,2005,115(6):1101-1103.Mitchell Int JPediatrOtorhinolaryngol,2004,68(11):1375-1379.张亚梅,王桂香.中国全科医学,2007,10(2):102-104.年幼儿因颅面生长快年幼儿因颅面生长快,应每应每6 6月评价月评价1 1次次不同年龄段nCPAP的成功率nCPAP简便易行,依从性好,在多数病例可长期应用Massa F,Arch Dis Child,2002;87:438443FT 失败例ST 成功例不同年龄段nCPAP的成功率Massa F,Arch Dis Child,2002;87:438443Craig AH,Neuropsychi Dis Treat,2006;2(3):30926Craig AH,Neuropsychi Dis Treat,2006;2(3):30926 Hoban TF,Neurologist,2005,11(6):325-337.Aviv DG,Am J Respir Crit Care Med,2005,172;364370Raanan A,Am J Respir Crit Care Med,2005,172;264265谢谢您的关注!