1、HodgkinsLymphomaNon-HodgkinsLymphomasAgeAverage age is 27.7 with two age peaks,the major one between 15 and 24 with a lesser peak after age 55.Average age is about 67.LifetimeprevalenceMen 0.23%Women 0.20%Men 2.12%Women 1.79%OccurrenceAbout 15%of all lymphomasAbout 85%of all lymphomasHodgkinsLymphom
2、aNon-HodgkinsLymphomasHodgkinsLymphomaNon-HodgkinsLymphomasAffectedLymphCells B-Lymphocytescharacterized by the Reed-Sternberg Cell B-Lymphocytes(90%),T-Lymphocytes or Natural Killer(NK)CellsSymptoms More likely(40%)to have systemic(B)symptoms at the time of diagnosis.Less likely than HL to have sys
3、temic(B)symptoms(27%)at the time of diagnosis.ProgressionLess likely to be diagnosed in stage IV(10%).Hodgkins disease usually progresses slowly(or aggressively)in an orderly way from one lymph node region to the next.If it spreads below the diaphragm,it usually reaches the spleen first;the disease
4、then may spread to the liver and bone marrow.If the disease starts in the nodes in the middle of the chest,it may spread outward to the chest wall and areas around the heart and lungs.More likely than HD to be diagnosed in stage IV(36%)but this will vary by NHL subtype.The Non-Hodgkins lymphomas are less predictable in their course than Hodgkins and they are more apt to spread(cyclophosphamide,doxorubicin,vincristine,and prednisolone)Purine analogues
