1、.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 2.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 3 Infections other than PML Immunogenicity and hypersensitivity reactions Carcinogenicity Post-ma
2、rketing reports of serious adverse events Summary of major safety concerns.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 4 Natalizumab-and placebo-treated patients had similar incidences of:infections overall:73.7%vs.73.9%(natalizumab vs.placebo)
3、serious infections:2.4%vs.2.3%Natalizumab-and placebo-treated patients had similar incidences of:upper respiratory tract infections:59.6%vs.59.8%UTIs:21.5%vs.21.4%serious UTIs:0.6%vs.0.5%gastroenteritis:9.1%vs.9.0%.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损
4、伤病人自发利尿现象的观察分析 5Incidences of specific infections in placebo-controlled studies:all lower respiratory tract infections:13.3%vs.12.2%(natalizumab vs.placebo)serious pneumonias:0.4%vs.0.2%vaginal infections:7.5%vs.6.2%all herpes infections:7.0%vs.6.1%gingival infections:1.1%vs.0.5%Atypical infections
5、cryptosporidial gastroenteritis with prolonged course(in monotherapy Study 1801)acute CMV infection with transaminitis(in open-label Study 1808).代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 6Incidence of infections overall:40.4%vs.35.8%(natalizu
6、mab vs.placebo)Incidence of serious infections:2.5%vs.2.6%Incidences of selected infections:URIs:27%vs.21%UTIs:2.9%vs.2.0%vaginal infections:2.1%vs.1.6%all herpes infections:1.6%vs.1.0%perianal abcesses:1.1%vs.0.6%serious viral meningitides:0.2%(2)vs.0 serious UTIs:0.2%(2)vs.0One serious CMV infecti
7、on(CMV colitis)Patient also receiving azathioprine.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 7Atypical InfectionsSix serious atypical lower respiratory tract infections Pneumonia with lung abscess Pulmonary aspergillosis Pneumocystis carinii
8、pneumonia Varicella pneumonia Mycobacterium avium intracellulare complex pneumonia Burkholderia cepacia infectionPossible tuberculosis infectionUnclear role of concomitant immunosuppressive/immunomodulatory agents and intercurrent illnesses.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质
9、激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 8Anti-natalizumab antibody formation assessed every 12 weeks in Phase 3 MS Studies and selected CD studies 10%of patients had a positive antibody titer at least once 4%of patients were transiently positive and 6%were persistently positive in MS Studies Incide
10、nce of anti-natalizumab antibody formation was higher in Study 1802(12%)than in 1801(9%)Intermittent(irregular)infusions may lead to higher incidence of antibody formation.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 9Anti-natalizumab antibody f
11、ormation strongly associated with infusion reactions and hypersensitivity reactions Infusion reactions occurred in 77%of persistently antibody-positive patients vs.20%of antibody-negative patients in MS Studies 1801 and 1802 Most frequent infusion reactions in antibody-positive patients:rigors,nause
12、a,headache,urticaria,flushing,pruritus,dyspnea Anaphylactic/anaphylactoid reactions occurred in 5.3%of antibody-positive patients vs.0 antibody-negative patients in MS Studies 1801 and 1802 Anaphylactic/anaphylactoid reactions occurred in 1.3%of antibody-positive patients vs.0 antibody-negative pati
13、ents in selected CD studies.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 10MS relapses reported more frequently as adverse events in antibody-positive patients(vs.transiently positive and antibody-negative patients)57%vs.35%(antibody-positive vs
14、.antibody-negative patients)Incidence of infections lower in antibody-positive patients(vs.transiently positive and antibody-negative patients)Overall infections in MS patients:69%vs.82%(antibody-positive vs.antibody-negative patients)Herpes infections in MS patients:2.7%vs.8.4%.代理报关委托书委托报关协议关于审理城镇房
15、屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 11Anaphylactic/anaphylactoid reactions MS placebo-controlled studies:0.4%(6)vs.0.2%(2)natalizumab vs.placebo CD placebo-controlled studies:0.1%(1)vs.0 Long-term CD studies:1 additional case of anaphylaxis(during first in
16、fusion in CD251;300 days after receiving 4 infusions in prior CD study)Skin and subcutaneous tissue disorder infusion reactions in MS placebo-controlled studies:4.6%vs.1.9%Urticaria:1.6%vs.0.3%Delayed hypersensitivity eventsMost hypersensitivity events occurred during or immediately after second inf
17、usion;some occurred later One case of anaphylaxis associated with 13th infusion.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 12 Malignancies balanced in natalizumab-and placebo-treated patients in placebo-controlled studies(0.7%natalizumab vs.1.
18、3%placebo)Types of malignancies observed in natalizumab-treated patients in all MS studies:Breast CA Basal cell CA Cervical CA Colon CA Melanoma Squamous cell CA Pituitary adenoma Papillary thyroid CA.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析
19、 13 Malignancies more frequently reported for natalizumab-treated patients in placebo-controlled studies(0.6%vs.0.2%)Types of neoplasms observed in natalizumab-treated patients in all CD studies:Breast CA Lung CA Bladder CA Colorectal CA Malignant melanoma Uterine CA Basal cell CA Squamous cell CA U
20、terine CA Renal cell CA(clear cell)Meningioma Craniopharyngioma(suspected)Lymphoma(B-cell).代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 14 B-cell lymphoma(1)49 yo man who received 6 infusions of natalizumab in Studies 307 and 351(9/04 2/05)Histo
21、ry of infliximab therapy(8 doses)Concomitant 6-mercaptopurine therapy Had submandibular lymphadenopathy during 9/04 screening examination;not apparent on subsequent exam Presented with painful lymphadenopathy August,2005 and was diagnosed(CT;biopsy)with B-cell lymphoma.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司
22、法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 15 Deaths Infections Herpes CNS infections Meningitis and encephalitis Malignancies Hypersensitivity reactions and other serious events.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象
23、的观察分析 16Types of infections suggest possible compromise in cell-mediated immunityHerpes infections,lower respiratory tract infections(especially those caused by atypical pathogens),and viral meningitides are of particular concernRole of concomitant medications and intercurrent illnesses in pathogene
24、sis of infections is unclearRelative risks for infections similar in MS Studies 1801(monotherapy)and 1802(combination therapy)No clear association between increasing number of natalizumab infusions and risk for infections.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒
25、症导致急性肺损伤病人自发利尿现象的观察分析 17Anti-natalizumab antibodies formed in approximately 10%of patientsPersistently positive anti-natalizumab antibodies associated with infusion reactions,hypersensitivity reactions,increased MS relapse/CD exacerbations,decreased incidence of infectionsAnaphylactoid reactions occ
26、urred in 0.4%of natalizumab-treated MS patients overall and in 5%of antibody-positive patientsHypersensitivity reactions most common with second infusion but may occur much later.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 18 No evident increas
27、e in risk for malignancies in MS studies One lymphoma(B-cell)in patient in long-term CD trial concomitant 6-mercaptopurine therapy and history of infliximab therapy No leukemias Longer exposures will be needed before risk for malignancies can be adequately assessed.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有
28、关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析 19Tysabri Review TeamRegulatory Project Manager(DNP)Product(DMA)Katherine Needleman,M.S.,RAC Elena Gubina,Ph.D.Chana Fuchs,Ph.D.Team LeaderClinical(DNP)Susan McDermott,M.D.Pharm/Tox(DNP)Alice Hughes,M.D.Barbara Wilcox,Ph.D.Wilson Brya
29、n,M.D.,Team Leader Lois Freed,Ph.D.,Team LeaderMarc Walton,M.D.,Ph.D.,Deputy DirectorRussell Katz,M.D.,Director Labeling(DDMAC)Catherine Gray,Pharm.D.Clinical Pharmacology(OCBP)Iftekhar Mahmood,Ph.D.RiskMAP Review Team(ODS)Hong Zhao,Ph.D.,Team LeaderStatistics(OPSS)Sharon Yan,Ph.D.Kun Jin,Ph.D.,Team
30、 Leader.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析注：文本框可根据需求改变颜色、移动位置；文字可编辑POWERPOINT模板适用于简约清新及相关类别演示.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析1234目录点击添加标题点击添加标题点击添加标题点击添加标题.代理报关委托书委托报关
31、协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析添加文本点击添加文本点击添加文本点击添加文本点击添加文本点击添加文本点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析添加文本点击添加文本点击添加文本点击添加文本点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计
32、及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析添加文本点击添加文本点击添加文本点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析添加文本点击添加文本点击添加文本点击添加文本点击添加文本点击添加文本点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致
33、急性肺损伤病人自发利尿现象的观察分析添加文本点击添加文本点击添加文本点击添加文本点击添加文本 点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析添加文本点击添加文本点击添加文本点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析添加文本点击添加文本点击添加文本点击添加文本点击添
34、加文本点击添加文本点击添加文本点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析添加标题添加文本点击添加文本点击添加文本点击添加文本点击添加文本.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳
35、务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析年会视频：http:/ 1、携手超越，驭领未来、携手超越，驭领未来2 2、你在我心里面、你在我心里面 -用心创造新未来用心创造新未来.代理报关委托书委托报关协议关于审理城镇房屋租赁合同纠纷案件司法解释有关劳务派遣制度设计及对劳务派遣行业的影响分析糖皮质激素在呼吸系统疾病中的合理应用严重脓毒症导致急性肺损伤病人自发利尿现象的观察分析年度总结：由公司各职能部门、高层做年度总结：由公司各职能部门、高层做09年总结报告，传递年总结报告，传递10年度公司战略发年度公司战略发展规划以及嘉许展规划以及嘉许09年度优秀员工年度优秀员工感谢晚宴：让员工在享受晚宴的同时，感谢晚宴：让员工在享受晚宴的同时，感受公司对他们一年来付出的感谢；让感受公司对他们一年来付出的感谢；让嘉宾感受耀光纺织的关注和企业文化嘉宾感受耀光纺织的关注和企业文化员工才艺秀：加强员工互动，展现员工员工才艺秀：加强员工互动，展现员工风采风采.
