1、v v v Click to add add Text；1,100,000 7.口腔崩解片的特点口腔崩解片的特点口腔崩解片口腔崩解片可影响药物可影响药物的溶解速率的溶解速率，如调节，如调节pH使药物在口使药物在口腔内以非离腔内以非离子形式存在子形式存在口腔崩解片不必口腔崩解片不必用水送服，唾液用水送服，唾液即可使其崩解或即可使其崩解或溶解，既可按普溶解，既可按普通片剂吞服，又通片剂吞服，又可放于水中崩解可放于水中崩解后送服。后送服。解热镇痛药阿司匹解热镇痛药阿司匹林在药物到达胃肠林在药物到达胃肠道之前能迅速崩解道之前能迅速崩解并分散成细微的颗并分散成细微的颗粒，造成药物在胃粒，造成药物在胃肠道
2、大面积分布，肠道大面积分布，吸收点增多，从而吸收点增多，从而降低了药物对胃肠降低了药物对胃肠道的局部刺激。道的局部刺激。2.服用方法服用方法3.肠道残留少肠道残留少副作用低副作用低1.吸收快吸收快生物利用度高生物利用度高。4.避免肝脏的避免肝脏的首过效应首过效应。常温下琼脂吸水常温下琼脂吸水膨胀，再干燥处膨胀，再干燥处理，制成的处理理，制成的处理琼脂琼脂(TAG)具有具有良好的崩解性。良好的崩解性。天然糖天然糖糖精钠糖精钠甜蜜素甜蜜素阿斯巴阿斯巴甜甜枸椽枸椽酸、酸、酒石酒石酸、酸、苹果苹果酸酸黄原胶黄原胶西黄蓍西黄蓍胶、阿胶、阿拉伯树拉伯树胶胶香草醛香草醛香兰素香兰素及其它及其它芳香型芳香型脂
3、类脂类、醇类醇类冷冻干冷冻干燥工艺燥工艺直接压直接压片工艺片工艺湿法制湿法制粒方式粒方式喷雾喷雾干燥干燥法法最常用最常用国外：国外：固体溶固体溶液技术液技术。二二三三一一。目的目的01方法方法02受试者选择受试者选择02：70%10%5%60%25%ThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.Text in hereText in hereText in hereText in hereClick to add TitleThemeGallery is a Design
4、 Digital Content&Contents mall developed by Guild Design Inc.ThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.ThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.Click to add TitleThemeGallery is a Design Digital Content&Contents m
5、all developed by Guild Design Inc.ThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.ThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.Click to add TitleThemeGallery is a Design Digital Content&Contents mall developed by Guild Desi
6、gn Inc.ThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.ThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.在在12-19天，天，给药前给药前8h和给药后和给药后4h禁食，试验期间禁食，试验期间为为标准餐。标准餐。在在12-19天，天，给药前给药前8h和给药后和给药后4h禁食，试验期间禁食，试验期间为为标准餐。标准餐。在在12-19天，天，给药前给药前8h和给药后和给药后4h禁食，试验期间禁食，试验期间为为标准餐。标准餐。
