1、 Professors Chen Chunming&Zhao Wenhua (On behalf of the Working Group on Obesity in China,ILSI Focal Point in China),Chinese Center for Disease Control and Prevention,Beijing ChinaPart I:Hypertension risk at BMI and waist circumference(WC)levelsInternational Life Science Institute Focal Point in Chi
2、na(ILSI FP-China)established a Working Group on Obesity in China(WGOC)in 2000.WGOC organized a meta analysis on the data from 13 big scale cross-sectional survey since 1990,under a protocol for analysis data collected among 239,972 adults aged 20-70 were included.Data source and analysis Analysis on
3、 disease risks factors,such as high blood pressure,diabetes including fast blood glucose(FBG),serum cholesterol,HDL-C,triglycerides(TG),in relation to BMI and waist circumference(WC)was carried out.Meta analysis of cohort studies covered 4 data sets with 76,227 adult subjects was done,the end points
4、 are total mortality,mortality of coronary heart disease,stroke and cancer,as well as incidences of coronary heart disease events and stroke events.Part of the results is presented here.The results on the prevalence of hypertension,and clustering of risk factors(high blood pressure,diabetes includin
5、g fast blood glucose(FBG),serum cholesterol,HDL,triglycerides)and BMI or waist circumference(WC)was presented as follows.SEX12STANDARD RATE OF HBP%01020304050BMI1718192021222324252627282930BMI and high blood pressureMale MaleFemaleThe prevalence of hypertension increased with increasing levels of BM
6、I.SEX12RATE OF HBP%102030405060waist60708090100WC and high blood pressureMaleFemaleThe prevalence of hypertension increased with increasing levels of WC SEX12STANDARD RATE OF RF=2%01020304050BMI1718192021222324252627282930BMI and risk factor clusteringMaleFemaleThe prevalence of clustering of risk f
7、actors increased with increasing levels of BMI.SEX12RATE OF RF=2%010203040506070waist60708090100WC and risk factor clusteringMaleFemaleThe prevalence of clustering of risk factors increased with increasing levels of WC.Population attributable risk percent(%)of hypertension at BMI levels Male Female
8、OR*PARP OR PARPBMI 24 3.69 45.9 2.76 38.4BMI 28 3.17 11.5 2.61 12.7*Age adjusted Population attributable risk%of hypertension beyond WC cutoffs OR*PARPMen WC85cm 3.44 41.3Women WC80cm 3.30 42.8*Age adjustedPart II:Correlation analysis of WC、BMI and blood pressureData source and analysisA study was c
9、onducted in Anhui and Henan provinces in 1996 by Chen Junshi and Zhao Wenhua.Totally 11,815 rural residents aged 40-79 were surveyed and information included blood pressure,high,weight and waist circumference,diet and blood sample were collected.The relationship between WC、BMI and blood pressure was
10、 analyzed.Correlation analysis of WC、BMI and blood pressure(male)MaleBMIWCrprpBMI-0.6390.001WC0.6390.001-SBP0.1860.0010.1890.001DBP0.2530.0010.2320.001FemaleBMIWCrprpBMI-0.6370.001WC0.6370.001-SBP0.2330.0010.1980.001DBP0.3040.0010.2220.001Correlation analysis of WC、BMI and blood pressure(Female)0 01
11、01020203030404050506060 18 18 18-18-19-19-20-20-21-21-22-22-23-23-24-24-25-25-26-26-*BMI%HPBMI、WC and Prevalence of Hypertension 0 01010202030304040505060607070 18 18 18-18-19-19-20-20-21-21-22-22-23-23-24-24-25-25-26-26-BMI%HP*0 01010202030304040505060607070 60 60 60-60-65-65-70-70-75-75-80-80-85-8
12、5-90-90-95-95-100-100-*0 0101020203030404050506060 60 60 60-60-65-65-70-70-75-75-80-80-85-85-90-90-95-95-100-100-*Combination of BMI and WC in relation to hypertension prevalence0 05 51010151565-65-70-70-75-75-80-80-85-85-90-90-95-95-22-22-23-23-24-24-25-25-WC%HP%HPBMICombination of BMI and WC in re
13、lation to hypertension prevalence(Male)Combination of BMI and WC in relation to hypertension prevalence(Female)0 05 51010151565-65-70-70-75-75-80-80-85-85-90-90-95-95-22-22-23-23-24-24-25-25-WC%HP%HPBMIWhen WC75cm,prevalence of hypertension increased significantly(P0.05).Hypertension prevalence%at v
14、arious WC levels with BMI24（male）0 05 510101515202065-65-70-70-75-75-80-80-85-85-90-90-95-95-WC2 42 4*Hypertension prevalence%at various WC levels with BMI24（female）0 05 51010151565-65-70-70-75-75-80-80-85-85-90-90-95-95-WC2 42 4At BMI 24,WC 80(male)WC 75(female),prevalence or hypertension dramatica
15、lly increased(p0.05 for all groups)Part III:Summary and Conclusion Data indicated application of Combination of BMI and WC will be the best predictor for hypertension risk,recommendation was made to set overweight cutoff at BMI 24;WC85 for men and 80cm for women as normal.Applying the classification,overweight(BMI24)prevalence is 30-40%,if BMI could be controlled under 24,38-45%hypertension of this population,33-37%of diabetes,45-50%risk factor clustering may be prevented.If the 8-12%obesity population(BMI 28)could be treated,15-17%risk factor clustering could be prevented.
