1、Based on the report Environmental Threats to Healthy Aging by Jill Stein MD,Ted Schettler MD,MPH,Maria Valenti and Ben RohrerGreater Boston Physicians for Social Responsibility(www.psr.org/Boston)and The Science and Environmental Health Network(www.sehn.org)Cowie 09,http:/apps.nccd.cdc.gov/DDTSTRS/d
2、efault.aspxhttp:/www.cdc.gov/nchs/FASTATS/lcod.htm,Hajjar 03Ford ES 05Alzheimers Assoc.Environment Drives Chronic DiseaseToxic exposuresoxidative stressObesity,hypertension,Cardiovascular disease,diabetesAlzheimers,dementia,ParkinsonsLow birth weightbuiltenvironmentdiseasestressenergychemicalsnutrie
3、ntsAltered PathwaysEnvironment Drives Chronic DiseaseEnvironmental FactorsChronic DiseaseCLASSICAL CONCEPTOF INFLAMMATION (2)Ross,Russell.Atherosclerosis An Inflammatory Disease.NEJM 1999,340(2);115-126.Environment Drives Chronic Disease “Hypothetical scheme of fat,fatty acid(6,3,trans and total)int
4、ake(as percentage of calories from fat)and intake of vitamins E and C(mg/d).Data were extrapolated from cross-sectional analyses of contemporary hunter-gatherer populations and from longitudinal observations and their putative changes during the preceding 100 years 75.”From AP Simopoulos,The importa
5、nce of the ratio of omega-6/omega-3 essential fatty acids.Biomedicine&Pharmacotherapy 56(2002)365-379.Years%of calories from fatmg/day Plasma Insulin,mg/dlTime,minsINSULINEMIC RESPONSELow glycemic foodHigh glycemic foodOmega-3,(Omega-6)Saturated fatAntioxidants High Glycemic CarbohydratesFructose En
6、vironment Drives Chronic DiseaseBrown 2006Uversky VN 2004Cory-Slechta 2005Baldi 2001 Baldi 2003Lee 2006,2007,2007 polycarbonate Endocrine Disruptors-BPA,dioxins,PCBs,some pesticides Saturated fatHigh Glycemic CarbohydratesAir PollutionAntioxidants Omega-3 Fructose SomePesticidesLead,other heavy meta
7、lsEnvironment Drives Chronic DiseaseFranco M et al.Impact of Energy Intake,Physical Activity,and Population-wide Weight Loss on Cardiovascular Disease and Diabetes Mortality in Cuba,1980-2005.AJE 166,12;Sept.19,2007Sustainable Food&Transportation Solutions:The Cuba Example FunctionUlrich 84Taylor 08
8、Mitchell 08 ObesityEndocrine Disruptors-BPA,dioxins,PCBs,some pesticides InactivitySaturated fatHigh Glycemic CarbohydratesAir PollutionAntioxidants Omega-3 Fructose Lead,other heavy metalsSomePesticidesEnvironment Drives Chronic DiseaseBerke EM 07,Molnar BE 04 ObesityEndocrine Disruptors-BPA,dioxins,PCBs,some pesticides InactivitySaturated fatHigh Glycemic CarbohydratesAir PollutionAntioxidants Omega-3 Fructose Lead,other heavy metalsSomePesticidesStress
