1、Alzheimers Disease阿尔茨海默症 2Ronald Wilson Ronald Wilson ReaganReagan罗纳德罗纳德威尔威尔逊逊里根里根第第40任（第任（第49-50届）美国总统届）美国总统 presidentpresident“I know Im on my way to the twilight. I know “I know Im on my way to the twilight. I know theres always a bright dawn ahead of the theres always a bright dawn ahead of the
2、United states. Thank you, my friends. May God United states. Thank you, my friends. May God bless you forever.”bless you forever.”brief introduction01PathogenyTreatment03Clinical manifestation02Other04Catalog4brief introduction15What?Alzheimers disease (AD) is a progressive neurodegenerative disorde
3、r .临床症状Clinical symptom记忆障碍dysmnesia失语aphasia失认agnosia执行功能障碍executive dysfunction痴呆dementiaThe disease usually begins after age 60, and risk goes up with age.6Two types Alzheimers disease(AD) 65 years old senile dementia(SDAT)65 years old7NameIn 1906,AD is named by Dr. Alois Alzheimer, a German doct
4、or. Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness.He found abnormal clumps. Scientists also have found other brain changes in people with AD.Nerve cells die in areas of the brain that are vital to memory and other mental abilities.8Clinical ma
5、nifestation29Clinical manifestation 期期期death1-31-3 yearsyears2-102-10 yearsyears8-12 8-12 yearsyearsMild Mild dementiadementiaModerate Moderate dementiadementiaSevere dementiaSevere dementiaMore women than men More women than men 7:54:67:54:6Disease for up to 10-20 yearsDisease for up to 10-20 years
6、Degradation of memory and cognitionWilliam Utermohlen的自画像的自画像Degradation of memory and cognitionWilliam Utermohlen is an American artist, in 1995 he was diagnosed with Alzheimers disease. Since then, he has decided to take advantage of the limited time available to retain memory and better understan
7、d himself through self portraits.William insisted the 5 New Year paintings self portrait, until completely forgotten how to draw. From the use of skilled drawing, dark portrayal of vivid features, to the same color, shape deformation, self portrait became more and more abstract (pictured above).Degr
8、adation of memory and cognition the effects of Alzheimers disease on the right parietal lobe of the brain are particularly severe, which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the brain.said Dr. Bruce Miller, a neurologist.His work became m
9、ore abstract, may be the parietal function damaged, causing blindness.What kind of changes have occurred in the brains of patients with dementia, which is not yet fully understood by the world s academia.PathogenyTreatment314Pathogenesis hypothesis of AD15PathogenyAbnormal amyloid beta cell depositi
10、on in neuronsAbnormal phosphorylation of tau proteinvsBeta amyloid (blue curve) and Tau Beta amyloid (blue curve) and Tau protein (orange curve) protein (orange curve) Research papers published in recent 30 Research papers published in recent 30 yearsyearsTreatmentincrease the concentration of acety
11、lcholine (Ach) in the brainpromoting survival of cholinergic neurons in the brain or improving their nerve conduction functionreducing the production or promoting degradation of beta amyloidOther419Still AliceFilmThe film tells the story of Alice Howland in seriously AD but still strong and brave .The film won the eighty-seventh Oscar award20The NotebookMemories of Tomorrow21Thankyou
