1、1245678 CkCVdtdcmm92mVdtdcCkVdtdcmmmVdtdc10CkCVdtdcmmdtVCkCdcmm)(itVCkCmmln积分以后得:1100ln CkCimCCVkVCCtmmm00lntkVCkCCCmmm303.2lg303.2lg00:改成常用对数,整理后12mmmVCVKtC1)(1中13mmmVCVKtCC中中)(mmKCtCVtC)(中14tkVCkCCCmmm303.2lg303.2lg00tkVCCmm0lnln15tkVCtkVCkCCmmmmm000lnln000lnCCkCCm)ln(000CCCKm1617CdtdXClECKCVVdtdX
2、mmE1CKVVClmm变慢。增高,有关,与非线性消除,药物的ClCCCl18CVVClm无关)与(CClKVVClmm.19KCCKCVVdtdXmmE1KVCKCVClmmKVCKVVCdtdXmmE120CCVkVCCtmmm00ln2ln2200002/102/1CCVkVCCtCCttmmm时,21mmVkCt2386.102/122dcVCkCdtmmCkCVdtdcmm23进行定积分到将时时该式当0,0,00tCtCCtt)2(.ln1000000000mmCmCmKCVCdCCCKCCVtdCCdtAUCVXC00)2(000VXKVVXCdtAUCmm24VVXKAUCmm02202VVXAUCm曲线下面积较大增加。剂量少量增加,会引起量平方成正比,表明:曲线下面积与剂25ssmssmCKCVX000XVXkCmmss增加。血药浓度以高于按比例表明:当剂量增加时,