1、药物设计学药物设计学分子生物学分子生物学结构生物学结构生物学基因组基因组生物信息学生物信息学数学数学统计学统计学药物化学药物化学有机药物化学有机药物化学计算机科学计算机科学计算化学计算化学分子药理学分子药理学一般药理学一般药理学NHHOCH2CH2NH23-(2-aminoethyl)-1H-indol-5-olNHHOCH2CH2NH2NHCH2CH2NH2HNONHCCH2CH2NH2OH2NNHCH2CH2NH2SHNOONHCH2CH2NSHNOOH2NNHNHNHNHOOHNNHOOCOOHH2NNHHNONOOCOOHHOH2NNHHNONOOCOOHCl3CCH2Trichlof
2、osOPOHOONaCl3CCH(OH)2水合氯醛Phenacetin体内代谢H3COCHNOC2H5ParacetamolH3COCHNOHNNImipramineNNHDesipramineNNHH2NPtH2NClClOONH3CO2CCH3OONHOOH2NNCocaineEucaineProcaineCH3CH3HNCONR0102030405060708090100C1 C2 C3 C4 C5 C6HRDuration of Anaesthesia (min)H11CH323C2H534C3H749C4H993050100150200250300350400450500C1 C2
3、C3 C4 C5 C6HOHCO2RRSpasmolytic activityCH38C2H512C3H724C4H998C5H11240C6H13410C7H15490C7OOOO-(CH2)n-CH3PON+O-O020040012006008001400100059 11 15 17 193Chain lengthInversionH2NOON+CH3H3CCH3NOON+H3CCH3CH3Bu-nn-BuCarbachol拟胆碱药拟胆碱药(降眼压）降眼压）Dibutoline抗胆碱药抗胆碱药(升眼压升眼压)InversionOHHOHNOHRR血压升高血压降低HCH3C2H5C3H7i
4、-C3H7C4H9i- C4H9NOCOOHC2H5FHNNNorfloxacinNOCOOHC2H5FNNH3CPefloxacinNOCOOHFNNOCH3H3COfloxacinOON(C2H5)2OOON(C2H5)2O奥 昔 拉 定 Oxeladin喷 托 维 林 Pentoxyverine止 咳CHOHCHNHCH3CH3OHNH3CEphedrine芬美曲秦 Phenmetrazine食欲抑制剂cinnamic acidOOHOOH3-phenylpropanoic acidH3CCOCH2CHOH3CCOCHCHOHH3CCOOHNNOOCH2CH2CH2CH3保泰松 Phen
5、ylbutazoneStyrylbutazoneNNOOCH2CH2CH2CH3OxacillinMethicillin,NOCH3OCH3OCH3R =NSCH3CH3COOHHNORO甲氧西林苯唑西林CH3NHCOCH2N(C2H5)2COOCH3CH3NHCOCH2N(C2H5)2ClTolicaine 托利卡因Butanilicaine 丁氯卡因CH3NHCOCH2N(C2H5)2CH3Lidocaine 利多卡因中枢积蓄致惊中枢积蓄致惊NSCH2CHN(CH3)2CH3NSCH2CHN+(CH3)3CH3Promethazine 异丙嗪Thiazinamium 噻丙胺抗过敏支气管扩张C OC CCNCNS OSOOSO2NRCONRCHCN5. Carboxylic acid group6. Thiourea7. Spacer group OOOHNHNOOONNOHCH3NOOHNNNNHCOOH SO2NHR SO3H PO(OH)NH2 PO(OH)OC2H5 CONHCNNHCNH2CHNO2NHCNH2NCNNHCNH2S8. Catechol9. Pyridine10. HydrogenHNNNOHONROHOOOHOHOHON+R3N+RNO2NH F
