1、 acetyl-glutamyl-glutamyl-methyoxylglutaminyl-arginyl-arginylamide(Argireline)在細胞外藉由影響鈣離子調控的胞吐作用（Calcium-dependent exocytosis）所需的蛋白質生成，進而抑制神經介質的釋放。藉由減少肌肉收縮而減少細紋和皺紋 SNARE complex 是膜上蛋白質調控神經胞吐作用的核心，因為此一複合物會導致（Catecholamine）的釋放，如果Catecholamine釋放太多就會導致皺紋以及細紋的形成；所以此類的胜肽就是抑制SNARE complex 生成 EGF:Epidermal
2、Growth Factor表皮細胞生長因子刺激老化皮膚細胞再活化刺激表皮細胞生長 刺激其他活細胞激素分泌刺激纖維母細胞分泌膠原蛋白及彈力蛋白刺激受傷組織血管增生，加速癒合傷口癒合過程中防止疤痕形成抗皺FGF:Fibroblast Growth Factor纖維母細胞生長因子皮膚再生刺激膠原蛋白及彈力蛋白合成刺激纖維母細胞生長刺激老化組織再生以及傷口癒合刺激表皮細胞生長及移動刺激毛髮生長，防止白頭髮形成刺激玻尿酸合成IGF:Insulin like Growth Factor類胰島素生長因子 扮演與生長荷爾蒙相同功能 刺激骨骼、肌肉及神經再生 刺激受傷組織血管增生 減緩腦下垂體老化 刺激玻尿酸合
3、成 刺激毛髮生長並預防落髮VEGF:Vascular Endothelial Growth Factor血管內皮細胞生長因子 血管內皮細胞生長因子是強力新血管生長因子 刺激血管細胞增生 刺激血管細胞移動TGF-3:Transforming Growth Factor-3 多功能的細胞激素 刺激細胞繁殖、生長及分化 去除疤痕的形成 協助傷口癒合奈米結構易滲透至皮膚內層，讓化妝品的效果再也不侷限在單純的表面功夫 奈米載體可使其成分滲透至真皮層與角質層交界處，對需要深層吸收才得以發揮的美白、防皺與塑身等功能，可以得到更有效的發揮 奈米化原料粒子 Nanoparticle Titanium dioxi
4、de、Zinc oxide、Iron oxide Mica and other metal oxide 奈米容器載體 Nanocarrier Liposome and ethosome Nanosome and micelle Fullerene 奈米化纖維材料Nanofiber Mask containing chitin/chitosan fiber Age gracefully?Not todays consumer,who often seeks anti-aging advice from her dermatologist who,more often than ever thes
5、e days,markets his or her own line of products.Sales of professional skin care products rose 13%in 2007,with anti-aging products leading the category.1.UnileverUnited Kingdom$25.48 billion2.LOralFrance$23.3 billion3.HenkelGermany$9.75 billion4.KaoJapan$9.6 billion5.Reckitt BenckiserUnited Kingdom$9.
6、42 billion6.BeiersdorfGermany$6.38 billion7.ShiseidoJapan$6.35 billion8.LVMHFrance$3.74 billion9.LionJapan$2.65 billion10.ChanelFrance$2.5 billion11.Yves RocherFrance$2.41 billion12.NaturaBrazil$2.2 billion13.GlaxoSmithKlineUnited Kingdom$2.1 billion14.AmorePacificKorea$1.78 billion15.KosJapan$1.58
7、billion16.ClarinsFrance$1.38 billion17.OriflameSweden$1.37 billion18.LGKorea$1.26 billion19.PuigSpain$1.21 billion20.Pierre FabreFrance$1.0 billion21.YSL BeautThe Netherlands$889 million22.PolaJapan$878 million23.PZ CussonsUnited Kingdom$828 million24.The Bolton GroupThe Netherlands$739 million25.Su
8、nstarJapan$637 million26.The Colomer GroupSpain$598 million27.MandomJapan$556 million28.LornameadUnited Kingdom$537 million29.MenardJapan$521 million30.FanclJapan$430 million Major Products:Personal careAxe/Lynx,Rexona/Sure and Degree deodorants;Dove,Caress,Lux and Lifebuoy soaps;Ponds and Vaseline
9、skin care products;Organics,Salon Selectives,SunSilk,Suave and ThermaSilk hair care products;Close-up and Signal oral care products.HouseholdAla,All,Omo/Persil and Surf laundry detergents;Comfort and Snuggle fabric softeners;Sunlight dish detergent,Domestos bleach,Cif cleaners.New Products:Vaseline
10、Cocoa Butter range,Clear anti-dandruff shampoo,Domestos Zero Limescale bleach.Major Products:LOral Paris,Garnier,Maybelline New York,SoftSheen Carson.LOral Professionnel,Krastase,Redken,Matrix,Mizani,Pureology LuxuryLancme,Biotherm,Helena Rubinstein,Kiehls,Shu Uemura,Giorgio Armani,Parfums Cacharel,
11、Ralph Lauren Fragrances,Paloma Picasso,Parfums Guy Laroche,Diesel,Victor&Rolf,Yue-Sai.Active CosmeticsVichy,La Roche-Posay,Skinceuticals,Sanoflore.LOrals operations also include The Body Shop and Galderma,and 50%stakes in Le Club des Crateurs de Beaut and Laboratoires Innov.New Products:LOral Profes
12、sionnel Color Supreme,LOral Professionnel Homme Cover 5 grey hair cover,LOral Paris Glam Shine,Derma Genesis/Skin Genesis,Lancme Rnergie Morpholift Rare line,LOral Professionnel Age Densiforce,La Roche-Posay Substiane anti-aging replenishing care,Maybelline Define-A-Lash,Lancme Virtuose mascara,Shu
13、Uemura Art of Hair,Mizani Butter Blend.Major Products:Laundry and home care sold under brands such as Persil,Purex,Dixan,Vernal,Mir Colueurs,Pril,Bref,Spee Weier,Riese and Somat.Cosmetics and toiletry brands include Schwarzkopf,Fa,Right Guard,Dial,Igora,Palette,Gliss,Kur,Schauma,Taft,Theramed and Di
14、adermine.New Products:Laundry Purex Natural Elements,Persil 20C formulation;Hair care Palette Golden Gloss Browns,Gliss Kur Oil Nutritive,Schuama Kiwi Glanz,Taft Volume Power,Drei Wetter Taft Sensitive,BlondMe Personal care Fa Naturals shower gel and deodorant,Dial Yogurt;Skin careDiadermine AgeExce
15、llium Oral careTheramed 2-in-1 freshness,Theramed Titan Fresh.Major Products:Household products,personal care products and color cosmetics.New Products:Sofina beaut,Sofina Primavista base makeup,Asience hair care(relaunched globally),Megurism steam eye mask,Attack Biogel liquid laundry detergent,Men
16、s Biore line(relaunched in Japan).Major Products:Surface care Cillit Bang,Lysol,Dettol,Harpic.Fabric care Calgon,Vanish,Resolve,Spray n Wash,Woolite.Dishwashing Finish,Electrasol Home care Airwik,Mortein Health and Personal care Veet,Dettols,Clearasil.New Products:Cillit Bang Grease&Floor,Dettol Her
17、bal soap and shower gel,Veet Pump Pack,Mortein with Dettol,Mortein Naturgard range,Airwick Freshmatic Mini.Major Products:Skin care,beauty care and toiletries sold under brand names that include Nivea,Eucerin,La Prairie,Slek,Labello,8x4,Florena.New Products:Nivea Diamond Gloss hair products;Nivea My
18、 Silhouette body shaping gel;Nivea for Men Extreme Comfort;Nivea For Men whitening oil control(India);Nivea for Men DNAge anti-wrinkle moisturizer;Nivea Good-Bye Cellulite dietary supplement capsules(U.S.only);Eucerin Hyaluron-Filler eye care.Major Products:Skin care,color cosmetics,sun care,fragran
19、ces,hair care and toiletries.Major brands include Shiseido,Carita,Decleor,IPSA,Ettusais,Dicila Parfums Issey Miyake,Parfums Jean Paul Gaultier,Parfums Narciso Rodriguez,Nars,Cle de Peau Beaute Za,Parfums Serge Lutens,Urara and Supreme Aupres.New Products:Cl de Peau Beaut La Crmes,Revital,Aqua Label
20、skin care,Acne&skin lightening series,Uno mens skin care,Tsubaki Golden Repair hair care,Urara Makeup,Shiseido BOP intensive skin collective program,Shiseido Zen fragrance(relaunch).Major Products:Fragrances and cosmetic sold under brands such as Christian Dior,Guerlain,Givenchy,Kenzo,Acqua di Parma
21、,Parfums Loewe,Benefit,Fresh and Makeup Forever.LVMH also owns Sephora,the beauty products retailer.New Products:Dior Fahrenheit 32 for men,Midnight Poison Addict Shine fragrances,Capture L Ore de Vie,Diorskin foundation,Backstage.Guerlain LInstant Magic,Eau de Shalimar,Aqua Allegoria Figue Iris and
22、 Aqua Allegoria Laurier Rglisse,Cruel Gardnia,Cherry Blossom delight,My Insolence.Parfums Givenchy Organza Jasmin 2007,Very Irresistible Rosa Damascena 2007,Amarige Mimosa 2007,Vetyver,Rouge Interdit lipstick.Parfums Kenzo Tokyo by Kenzo for men,Vintage Edition.Benefit Love Your Look,That Gal face b
23、rightening primer.Makeup Forever Aqua Eyes waterproof eyeliners.Acqua de Parma Colonia Intensa.Parfums Loewe Quizas,Quizas Quizas.Fendi Palazzo and Pucci Vivara fragrances.Major Products:Oral care(toothpastes,toothbrushes mouthwashes,breath fresheners,dental needs);beauty care(shampoos,conditioners,
24、treatments,hair styling products,mens hair care,soap,body washes,skin care,antiperspirants and deodorants);fabric care(laundry detergents and additives,bleaches,fabric softeners);home care(dishwashing detergents,disinfectants,household cleaners,kitchen-related products)and insecticides.New Products:
25、Household Soflan with Fragrance and Deodorant fabric softener,Top Kaori Tsuzuku chamomile-scented liquid laundry detergent with fabric softener,Look O2 Cleaner(joint product with Henkel),Charmy gel-based dishwasher cleaner/detergent.Oral care Dentor Systema EX Extra Herb,Medish oral care gum.Persona
26、l care Ban Deodorant Mist,Ban Refresh Powder Sheets,Bathology skin care,Pro Tec Head mens hair care.Major Products:Skin care,color cosmetics and fine fragrances.New Products:Skin care Sublimage Essential Regenerating Cream,Hydramax+Active moisture tinted lotion SPF 15 Color cosmetics Facettes dor na
27、il color;Robertson Boulevard limited edition nail collection Fragrance Allure pour Homme Edition Blanche,Chance Eau Frache,Allure Homme Sport Cologne Sport,No.5 Eau Premire.Major Products:Skin care,cosmetics and fine fragrances marketed under the brand names of Yves Rocher,Daniel Jouvance,Dr.Pierre
28、Ricaud and Kiotis.New Products:Fragrance Naturelle,Comme une vidence Homme.Personal care Plaisirs Nature Kiwi eau de toilette and shower gel Skin care Culture Bio.Major Products:Natura Ekos,Natura Tododia,Natura Chronos,Natura Mame e Beb,Natura Diversa,Natura Amor Amrica.New Products:Natura Amor Amr
29、ica,Natura Natur,Natura Tododia,Natura Diversa Hidratao Prolongada,Natura Chronos Politensor de Soja,Natura Aguas,Natura Fixplant,Natura Faces,Natura Mame e Bebe,Natura Ekos Cacau,Natura Homem Chromo,Natura Erva Doce Hidratante Facial,Natura Crer Para Ver Bolsa Amiga do Meio Ambiente.Major Products:
30、Toothpaste and mouthwash Aquafresh,Dr.Best,Macleans,Odol,Odol Med 2,Polident,Polygrip,Sensodyne Denture care Polident,Polygrip,Corega.New Products:Aquafresh iso-active foaming gel Major Products:Skin care and makeup Laneige,Iope,Mamonde,Innisfree,Hera,Lirikos.Fragrances Lolita,Lempika,Castel Bajac,E
31、spoir.New Products:Sulwhasoo su Essence,ioPE Whitegen RXC,V=B Yeginseng,premium makeup from Laneige,Happy Bath Blue Spa Essential Body Cleanser.Major Products:Skin care,cosmetics and toiletries.New Products:Junkisui skin care.Major Products:Skin care,fine fragrance,color cosmetics and sun care sold
32、under brand names such as Clarins,Thierry Mugler,Azzaro,Stella Cadente and My Blend.New Products:My Blend customizable skin care Major Products:Skin care,fragrances,color cosmetics,toiletries and accessories.New Products:Enigma and Radiant Lights fragrances,Optimals Radiance Glow self tanner,Lift Ex
33、pert,Perfect Body,Lash Extreme,Royal Velvet Intensive Revitalizing Cloth Mask.Also,Diamond Musk,Silky Kiss lipstick,Diamond Cellular Anti-aging cream and Dermoprofessional Bio-Peeling Kit(all in September).Major Products:Household laundry and dishwasher detergent,fabric softener,kitchen cleaners.Per
34、sonal care toothpaste,shampoo,soap,baby care,skin care,color cosmetics and toiletries.New Products:su:m 37 fermented cosmetics,Borrowing Earth household products.Major Products:Fragrances Adolofo Dominguez,Agatha Ruz de la Prada,Ague Brava,Anouk,Antonio Banderas,Barbie,Carmen Sevilla,Don Algodon,Maj
35、a,Mango,Massimo Dutti,Pach,Quorom,Roasiro Flores,Sportman,Victori&Lucchino,Zara,Boston Man,1916,Antonio Miro,Azur de Puig,Brummel,Eau dEte,Equinox,Farala,Springfield,Yacht Man Blue,Zinnia.Personal Care Payot,Dennenes,Heno de Pravia,Lactovit,Vitese,Kinesia,Maja,Agua Lavanda Puig,Maderas,Misslyn,Nelia
36、,VF.New Products:Blue Seduction for Women Major Products:Skin care and hair care products sold under the Avne,Ducray,Pierre Fabric Dermatologie,Klorane,Galnic and Rne Furterer banners.Comments:Pierre Fabres Dermo-Cosmetics unit earmarks 5%of its sales for research projects,which are conducted at its
37、 centers in Vigoulet-Auzil and Saint-Jacques Hospital in Toulouse.Research conducted in Toulouse is made possible through an agreement between the Pierre Fabre group,the local university hospital and Toulouse University.Major Brands:Fragrances,cosmetics and skin care products.Brands include Yves Sai
38、nt Laurent,Roger&Gallet,Stella McCartney,Alexander McQueen,Boucheron and Ermenegildo Zegna.New Products Fragrance Yves Saint Laurent Elle,Paris Nuit de Fete,Paris Pont des Amours,Opium Poesie de Chine Eaux dOrient,LHomme Yves Saint Laurent Eau dt 2008,Elle Yves Saint Laurent summer fragrance 2008,Ci
39、nma Scnario dt,Baby Doll Magic;Ermenegildo Zegna Z Zegna Fresh;Stella McCartney Stella Sheer 2008.CosmeticsLipTwins.Major Products:Skin Care Alvita,Whitissimo,Day+Day Vitax,Botanex,1/f,Plenna,Polissima,BA,Signs Solution 28 Carats,Signs Solution Wrinkle Shot,Evangile Cosmetics Whitissimo,Silfique,Viv
40、oke,Aniak,Maquifard,Super Suncare,Southern Call Body Care Feel&Heal;Hair CareIdea Style,Simfree Hair Color Mens Care Galantom,GR Shot S.New Products:Whitissimo base makeup.Major Products:Personal care products sold under brands including Imperial Leather,Joy,Cussons Kids,Premier,Carex,Baby,Luksja,Ma
41、kler,Sweet Seventeen,Venus Hair,Original Source.Household product brands including Morning Fresh,Elephant,E,Radiant,Robb,Duck and Minerva.New Products:Imperial Leather SkinBliss.Major Products:Laundry care productsOmino Bianco,Merito,Nibro Bathroom/kitchen care and cleanersWC Net,Fornet,Last,Dubro,S
42、olivaisselle Surface&Floor CareCarolin,SMAC,Overlay,Vetril,WC Eend Household soap productsCyclon,Dorn.Personal CareNeutro Roberts,Borotalco,Rog Cavaills,Sanogyl,Somatoline,Roberts Fragrance,Acque Alle Rose Robert,Citrosil,Botot,Wetties,Soapy,Silx BeautyCollistar skin care,makeup,hair care.New Produc
43、ts:CollistarLong Lasting Color Line and Nourishment and Lustre Lines for hair care,Body Energizing Treatment for men,Global Anti-Age Protection Tanning Face Cream SPF 30-50+,Supertanning Moisturizing Dry Oil SPF 15,Sun Effect Make-Up line,Topgloss Stick Reflex,Magnifica Patch-Lifting-Dermal Filling
44、Repairing Face and Neck Mask,Perfecta Active Neck and Dcollet Cream,Magic Drops self-tanning concentrate,Brightening Touch highlighting concealer,Eye Contour Lifting Treatment for men,Perfect Adherence Shaving Foam,Moisturizing Soothing Sensitive Skins,Perfect Adherence Shaving Foam,Moisturizing Sof
45、tening Tough Beards,Extreme Supermascara,Anti-Time 360 for Men.Rog CavaillsDermatological Deo-Care deodorant.Major Products:Oral care and beauty care products.Major Products:Hair and nail care products.Professional Revlon Professional,Intercosmo,Modern Organic Products,American Crew,D:FI,Creative Na
46、il,Tigi Consumer Fermodyl,Fixpray,Flod,Geniol,Lanofil,Llongueras,Natural Honey,Revlon Flex,ZP11 Cosmetics BioPoint,Burberry(license),Gatineau(license),Revlon(license);St DuPont(license),Ultima II(license)Multicultural African Pride,Arosci,Creme of Nature,Fabu-Laxor,Revlon Realistics,Special Feeling.
47、New Products:Crme of NatureRed Clover and Aloe Daily Breakage Relief and Jojoba&Olive Oil Moisture Active Deep Conditioning treatment;African PrideMiracle Deep Conditioning No Lye Relaxer System with Healing&Hydrating African Herbs.Major Products:Mens toiletriesGatsby and Lucido and Womens toiletrie
48、sLucido L,Produce,Pixy and Simplity.Major Products:Hair care Aqua Net,Finesse,Harmony,Lypsyl,Vosene.Cosmetics and skin care CD,Handsan,Tura.Fragrance and bathWoods of Windsor,Yardley.Oral Care Brilliant,Rapid White.New Products:Vosene new shampoo range,Finesse revitalizing shampoo,LypSyl Beeswax lip balm.Major Products:Skin care,cosmetics and fragrances.Major Products:Cosmetics and skin care products sold under the Attenir,Fancl and Nicostar banners.New Products:Fancl Sunguard SPF 30.
