1、5年生存率：年生存率：50-75%3年生存率年生存率:50%1年生存率年生存率:50%中位生存时间中位生存时间3月月颗粒性栓塞剂是TACE治疗的关键因素Hepatic arterial embolization with small particles to cause terminal vessel blockade is an effective treatment method for patients with unresectable HCC.These data support our hypothesis that particles alone may be the criti
2、cal component of catheter-directed embolotherapy.Journal of Vascular and Interventional Radiology.2008-06-01,Volume 19,Issue 6,Pages 862-869,.Transcatheter Arterial Embolization with Only Particles for the Treatment of Unresectable Hepatocellular Carcinoma.Mary A.MaluccioMD,MPH,Anne M.CoveyMD.Leah B
3、en PoratPhD Embosphere微球增加肿瘤缺血效果Transarterial embolization using one permanent embolic agent alone enhances tumour ischaemia and spares patients with hepatocellular carcinoma form toxic chemotherapeutic drugsDigestive and Liver Disease.2009-02-01,Volume 41,Issue 2,Pages 143-149,Transarterial emboliz
4、ation with microspheres in the treatment of monofocal HCC.A.Nicolini,P.Fasani,iJVIR，2008;19:1490-1496 100-300um的Embosphere微球能够进入肿瘤内部单纯微球栓塞终点让微球完全进入肿瘤内部，实现末梢真正的末梢栓塞慢打，用小注射器，连接三通合适的微球粒径，100-300um常用病例1男性，51岁。乙肝病史二十年，AFP490 ng/ml，肝硬化，病理：肝细胞癌单纯单纯Embosphere微球栓塞微球栓塞单纯单纯Embosphere微球栓塞微球栓塞单纯单纯Embosphere微球栓塞微
5、球栓塞单纯单纯Embosphere微球栓塞微球栓塞病例2男性，43岁。乙肝病史十五年，AFP5.8 ng/ml，病理：中分化肝细胞癌单纯单纯Embosphere微球栓塞微球栓塞单纯单纯Embosphere微球栓塞微球栓塞单纯单纯Embosphere微球栓塞微球栓塞单纯单纯Embosphere微球栓塞微球栓塞病例3女性，40岁。布-加综合征五年，肝右叶占位，AFP59.8 ng/ml，病理：肝细胞癌单纯单纯Embosphere微球栓塞微球栓塞单纯单纯Embosphere微球栓塞微球栓塞单纯单纯Embosphere微球栓塞微球栓塞病例4男性，40岁。肝左叶IV肝癌，门静脉坐支IV段瘤栓，AFP12
6、8 ng/ml单纯单纯Embosphere微球栓塞微球栓塞病例5男性，48岁。乙肝病史二十五年，AFP245.3 ng/ml，病理：低分化肝细胞癌单纯单纯EmboSphereEmboSphere栓塞栓塞单纯单纯EmboSphereEmboSphere栓塞栓塞2016.18各50例比较 单纯EmboSphereEmboSphere栓塞栓塞 碘油+明胶海绵栓塞发热 12 36腹痛 9 21总胆红素升高 6 11白蛋白降低 5 13转氨酶升高 12 23胆碱酯酶降低 2 5单纯栓塞与碘油单纯栓塞与碘油+明胶海绵栓塞术明胶海绵栓塞术后反应及肝功能影响比较后反应及肝功能影响比较小结EmboSphere栓塞方法；推荐小粒径（100-300um）；肝功能影响小EmboSphere栓塞后36月会出现复发，注意随诊单纯EmboSphere栓塞只处理可见肿瘤，有可能遗漏肿瘤卫星灶单纯Embosphere微球栓塞应用前景广阔
