12345Packer M,Coats AJ,Fowler MB et al.Effect of carvedilol on survival insevere chronic heart failure.N Engl J Med.2001;344:1651-1658.6Packer et al,200201020304050ImprovedUnchangedWorsenedCarvedilolPlacebo%of patients7Clinical ResponderClinical non-ResponderNYHA1 classEcho-Responder LVESV 15%Echo-nonResponderBleeker G et al,Am J Cardio 2006;97:2608910111213141516Bleeker et al,JCE 2004;15:544171819202122232021/3/8
