1、1 3D ASL研究进展研究进展2 p采用采用可弥散的示踪剂进行成像的方法可弥散的示踪剂进行成像的方法p15O-Water PETpXenon CTpASL MRIp99Tc-HMPAO SPECT（Microsphere-like tracers）p采用不采用不可弥散的示踪剂进行成像的方法可弥散的示踪剂进行成像的方法pCTPpDSC MRI3 p采用采用可弥散的示踪剂进行成像的方法可弥散的示踪剂进行成像的方法p15O-Water PET 放射性损伤、成本高放射性损伤、成本高pXenon CT 放射性损伤、舒适性差放射性损伤、舒适性差pASL MRIp99Tc-HMPAO SPECT（Micr
2、osphere-like tracers）放射性损伤、半定量放射性损伤、半定量p采用不采用不可弥散的示踪剂进行成像的方法可弥散的示踪剂进行成像的方法pCTPpDSC MRI4 pPulsed ASL(PASL)脉冲式脉冲式pContinuous ASL(CASL)连续式连续式pPseudo-continuous ASL(PCASL)准连续式准连续式SNRACCURACYSARPASL+CASL+PCASL+5 3D ASL 传统传统ASL采用采用EPIEPI采集，磁敏感伪影采集，磁敏感伪影明显明显2D2D采集，成像范围有限采集，成像范围有限对运动伪影敏感对运动伪影敏感采用采用FSEFSE采集，
3、有效克服采集，有效克服磁敏感伪影磁敏感伪影3D3D采集，大范围成像采集，大范围成像SpiralSpiral采集高效快速，有采集高效快速，有效克服运动伪影效克服运动伪影 图像信噪比明显提高图像信噪比明显提高 图像质量不稳定图像质量不稳定6 3D ASL临床应用临床应用7 脑膜瘤脑膜瘤海绵状血管瘤海绵状血管瘤301病例病例8 星形细胞瘤星形细胞瘤,WHO II 级级星形细胞瘤星形细胞瘤,WHO III 级级301病例病例9 301病例病例10 11 301病例病例12 13 14 301病例病例15 16 Lou X,Ma L,et al.Differential Diagnosis of MEL
4、AS and Ischemic Stroke using 3D Pseudocontinuous Arterial Spin Labeling.ISMRM Scientific Meeting,Italy,2014301病例病例17 18 p N=8 healthy volunteers(7M,1F,27-41Y)p PCASL,BS,3D spiral FSE p 3 Scans on 2 scanners,10-15 days apartPLD =2.5SPLD =1.5S1st test (scanner 1)2nd test (scanner 2)3rd test (scanner 1
5、)100806040200100806040200PLD =1.5SPLD =2.5S100806040200PLD =1.5SPLD =2.5SSubject 1Subject 2Subject 3100806040200PLD =1.5SPLD =2.5SSubject 419 Wu B,Lou X*,Wu XH,Ma L.Intra-and inter-scanner reliability and reproducibility of 3D whole-brain pseudo-continuous arterial spin-labeling MR perfusion on 3T.J
6、 Magn Reson Imaging.2014;39(2):402-9.20 u Huang DD,Wu B,Shi KN,Ma L Lou X*.Reliability of Three-dimensional pseudo-continuous arterial spin labelling MR imaging for measuring visual cortex perfusion on two 3T scanners.PLOS ONE.2013;8(11):e79471u HuangDD,Lou X*,Ma L,etc.RSNA,2013,Oral presentation21
7、22 PLD=1.5SPLD=2.5S301病例病例23 Lou X,Ma L.Can 3D pCASL be another predictor to evaluate the collateral Perfusion in Patients with severe intracranial arterial stenosis?ISMRM Scientific Meeting,Italy,2014301病例病例24 u Hernandez D a,etc.Pseudocontinuous arterial spin labeling quantifies relative cerebral
8、blood flow in acute stroke.Stroke.2012;43:7538.u Wang DJ,etc.The value of arterial spin-labeled perfusion imaging in acute ischemic stroke:comparison with dynamic susceptibility contrast-enhanced MRI.Stroke.2012;43:101824.u Bokkers RPH,etc.Whole-brain arterial spin labeling perfusion MRI in patients
9、 with acute stroke.Stroke.2012;43:12904.p有很好的一致性有很好的一致性pCBF的侧值无明显差异的侧值无明显差异pASL 更有利于显示治疗后的过度灌注更有利于显示治疗后的过度灌注(luxury perfusion)25 Musiek ES,etc.Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimers disease.Alzheimers D
10、ement.2012;8:51-9.26 Maja A.A.Binnewijzend,etc.Cerebral Blood Flow Measured with 3D Pseudocontinuous Arterial Spin-labeling MR Imaging in Alzheimer Disease and Mild Cognitive Impairment:A Marker for Disease Severity.Radiology 2013;267:221230.p70 Subjects with Subjective Complaints p31 Patients with
11、MCI p71 Patients with AD27 p脑发育过程中全脑发育过程中全脑脑CBFCBF的变化的变化p脑发育过程中扣脑发育过程中扣带回和枕叶的变带回和枕叶的变化化28 pASL技术进行脑灌注成像准确无创技术进行脑灌注成像准确无创p在在ASL技术中技术中PCASL序列序列SNR高，高，SAR较低较低pPCASL序列的可重复性好序列的可重复性好pPCASL序列扫描参数选择中序列扫描参数选择中PLD是关键是关键pASL临床应用范围广泛临床应用范围广泛29 p 灌注成像在食物、药物药代动力学方面灌注成像在食物、药物药代动力学方面的应用的应用p State and trait(phenoty
12、pe/genotype)effects状态与特质（表型与基因型）效状态与特质（表型与基因型）效应对应对CBF的影响的影响p Perfusion-based fMRI30 31写在最后写在最后成功的基础在于好的学习习惯成功的基础在于好的学习习惯The foundation of success lies in good habits谢谢聆听 学习就是为了达到一定目的而努力去干,是为一个目标去战胜各种困难的过程,这个过程会充满压力、痛苦和挫折Learning Is To Achieve A Certain Goal And Work Hard,Is A Process To Overcome Various Difficulties For A Goal
