脂肪脂肪41%肝脏肝脏47%Circulation 72:1064,1985Candinas R et al.Myocardial amiodarone concentrations after short and long-term treatment in patients with end stage heart failure.Eur J Clin Pharmacol,1998;53:331心肌心肌AMAM和和dAMdAM的含量与的含量与AMAM的累积量相关性好的累积量相关性好,与血浆药物浓度相关性与血浆药物浓度相关性差差.监测监测AMAM累积量较监测血药浓度更有临床意义累积量较监测血药浓度更有临床意义胺碘酮及其代谢产物的分布胺碘酮及其代谢产物的分布谢谢!谢谢!