1、 SDB交感神经张力交感神经张力血压升高血压升高心肌缺血心肌缺血心律失常心律失常心脏负荷增加心脏负荷增加心肌肥厚心肌肥厚收缩功能受损收缩功能受损舒张功能受损舒张功能受损CHF Pinsky MR.Augmentation of cardiac function by elevation of intrathoracic pressure.-J Appl Physiol,1983,54:950-955Baratz DM.Effect of nCPAP on cardiac output and oxygen delivery in patients with congestive heart f
2、ailure.-Chest,1992,102:1397-1401Bradley TD.Cardiac output response to CPAP in congestive heart failure.-Am Rev Respir Dis,1992,145:377-382Malone S.SDB in patients with dilated cardiomyopathy:effects of continuous positive airway pressure.-Lancet,1991,338:1480-1484Pand D.The effect of CPAP support on
3、 mortality and the need for intubation in cardiogenic pulmonary edema:a systematic review.-Chest,1998,114:1185-1192.Bersten AD.Treatment of severe cardiogenic pulmonary edema with continuous positive airway pressure delivered by face mask.-N Engl J Med,1991,325:1825-1830Granton JT.CPAP improves insp
4、iratory muscle strength in patients with heart failure and central sleep apnea.-Am J Respir Crit Care Med,1996,153:277-282Hammond MD.Respiratory muscle strenght in congestive heart failure.-Chest,1990,98:1091-1094.Naughton MT.Effects of nasal CPAP on sympathetic activity in patients with heart failu
5、re and central sleep apnea.-Am J Respir Crit Care Med,1995,152:473-479Osterziel KJ.Baroreflex sensitivity and cardiovascular mortality in patients with mild to moderate heart failure.-Br Heart J,1995,73:517-522Carlson JT.Depressed baroreflex sensitivity in patients with obstructive sleep apnea.-Am J
6、 Respir Crit Care Med,1996,154:1490-149639例急性肺水肿，随机对照研究，无创通气治疗组效果显著。-N Engl J Med,1991,325:1825-1830100例急性肺水肿，随访一年，CPAP 组血气改善明显，心脏指数增加，人工气道的需要减少。-Chest,1995,107:1379-1386无创通气治疗减少人工气道危险性的26%，并有减少死亡率的趋势。-Chest,1998,114:1185-1192 1、CHF伴SDB2、CHF伴CSR-CSA3、CHFEffect of CPAP on LVEFKaneko et al.N Engl J Med,2003;348:1233-41
