1、贮尿期表现贮尿期表现排尿期表现排尿期表现排尿排尿踌躇踌躇尿中断尿中断尿线细尿线细尿不尽尿不尽尿淋漓尿淋漓尿潴留尿潴留贮尿期症状原因贮尿期症状原因膀胱原因膀胱原因尿道原因尿道原因膀胱过动症膀胱过动症感觉性尿急迫感觉性尿急迫低顺应性低顺应性过度移动过度移动括约肌乏力括约肌乏力排尿期症状原因排尿期症状原因膀胱功能异常膀胱功能异常尿道或括约肌功能异常尿道或括约肌功能异常收缩无力收缩无力梗阻梗阻 。图1 图2 Kaplan SA,Roehrborn CG,Rovner ES,et al.Tolterodine and tamsulosin for treatment of men with lower
2、urinary tract symptoms and overactive bladder:a randomized controlled trial.JAMA 2006,296:23192328.Antimuscarinic Agents Tolterodine(Detrol LA)Oxybutynin(Ditropan XL,Oxytrol patch)Trospium(Sanctura)Solifenacin(Vesicare)Darifenacin(Enablex)Botulinum Toxin Potent Neurotoxin(1 gm in aerosol form could
3、kill 1,000,000 people)Has been used mostly in Neurogenic patients primarily to treat Neurogenic Detrusor Overactivity,BPH Neurogenic Patients with DSD Several subtypes(BTX-A&BTX-B)available.Resistance has been reported。五、五、MRMR阻滞剂之应用阻滞剂之应用 五、五、MRMR阻滞剂之应用阻滞剂之应用 前列腺增前列腺增生患者贮生患者贮尿期逼尿尿期逼尿肌稳定，肌稳定，排尿期逼排尿期逼尿肌有反尿肌有反射伴外括射伴外括约肌协调，约肌协调，TLTL值值1.641.64 尿频、排尿频、排尿困难诊尿困难诊断失调性断失调性排尿女性排尿女性2222岁患者岁患者贮尿期逼贮尿期逼尿肌稳定，尿肌稳定，排尿期逼排尿期逼尿肌有反尿肌有反射伴外括射伴外括约肌失调，约肌失调，TLTL值值-1.24-1.24；
