1、NEJM 1993;329:987NEJM 1993;329:987*年龄年龄0.05P0.05P0.05P0.05DLBCLDLBCL60806080岁岁aaIPIaaIPI 1 1 n=600n=600 R-CHOP14 R-CHOP14 q2w q2w 8 8 R-CHOP R-CHOP2121 q3w q3w 8 8随机化随机化至少观察至少观察1 1年年DelarueDelarue et al et al.Blood Blood 2009 114:Abstract 406.2009 114:Abstract 406.p=NSp=NSp=NSp=NSp=NSp=NSp=NSp=NSDel
2、arue et al.Blood 2009 114:Abstract 406.DLBCL:DLBCL:基因表达与预后基因表达与预后Rosenwald A et al.N Engl J Med.2002;346:1937-1947.ActivatedB-celllikeType 3Germinal-centerB-celllikeOverall survival(years)Probability02468101.00.50.0HighLevel of geneexpressionLowGerminal-centerB-celllikeType 3ActivatedB-celllikeGenes+-CD10BCL-6MUM1GCBGCBNon-GCBNon-GCB Hans CP,Blood,2004,103(1):275-282
