1、Alzheimers Disease阿尔茨海默症 1Ronald Wilson Ronald Wilson ReaganReagan罗纳德罗纳德威尔威尔逊逊里根里根第第40任（第任（第49-50届）美国总统届）美国总统 presidentpresident“I know Im on my way to the twilight.I know“I know Im on my way to the twilight.I know theres always a bright dawn ahead of the theres always a bright dawn ahead of the Uni
2、ted states.Thank you,my friends.May God United states.Thank you,my friends.May God bless you forever.”bless you forever.”2brief introduction01PathogenyTreatment03Clinical manifestation02Other04Catalog3brief introduction14What?Alzheimers disease(AD)is a progressive neurodegenerative disorder.临床症状Clin
3、ical symptom记忆障碍dysmnesia失语aphasia失认agnosia执行功能障碍executive dysfunction痴呆dementiaThe disease usually begins after age 60,and risk goes up with age.5Two types Alzheimers disease(AD)65 years old senile dementia(SDAT)65 years old6NameIn 1906,AD is named by Dr.Alois Alzheimer,a German doctor.Dr.Alzheimer
4、 noticed changes in the brain tissue of a woman who had died of an unusual mental illness.He found abnormal clumps.Scientists also have found other brain changes in people with AD.Nerve cells die in areas of the brain that are vital to memory and other mental abilities.7Clinical manifestation28Clini
5、cal manifestation 期期期death1-31-3 yearsyears2-102-10 yearsyears8-12 8-12 yearsyearsMild Mild dementiadementiaModerate Moderate dementiadementiaSevere dementiaSevere dementiaMore women than men More women than men 7:54:67:54:6Disease for up to 10-20 yearsDisease for up to 10-20 years9Degradation of me
6、mory and cognitionWilliam Utermohlen的自画像的自画像10Degradation of memory and cognitionWilliam Utermohlen is an American artist,in 1995 he was diagnosed with Alzheimers disease.Since then,he has decided to take advantage of the limited time available to retain memory and better understand himself through
7、self portraits.William insisted the 5 New Year paintings self portrait,until completely forgotten how to draw.From the use of skilled drawing,dark portrayal of vivid features,to the same color,shape deformation,self portrait became more and more abstract(pictured above).11Degradation of memory and c
8、ognition the effects of Alzheimers disease on the right parietal lobe of the brain are particularly severe,which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the brain.said Dr.Bruce Miller,a neurologist.His work became more abstract,may be the pa
9、rietal function damaged,causing blindness.What kind of changes have occurred in the brains of patients with dementia,which is not yet fully understood by the world s academia.12PathogenyTreatment313Pathogenesis hypothesis of AD14PathogenyAbnormal amyloid beta cell deposition in neuronsAbnormal phosp
10、horylation of tau proteinvs15Beta amyloid(blue curve)and Tau Beta amyloid(blue curve)and Tau protein(orange curve)protein(orange curve)Research papers published Research papers published in recent 30 in recent 30 yearsyears16Treatmentincrease the concentration of acetylcholine(Ach)in the brainpromot
11、ing survival of cholinergic neurons in the brain or improving their nerve conduction functionreducing the production or promoting degradation of beta amyloid17Other418Still AliceFilmThe film tells the story of Alice Howland in seriously AD but still strong and brave.The film won the eighty-seventh Oscar award19The NotebookMemories of Tomorrow20Thankyou21
