1、Efficient Demineralization A Challenge For Fermentation Products1Efficient Purification A Challenge For Fermentation Products高效分离纯化工艺- 面对发酵行业对化学品消耗及收率的挑战November 20122012年11月Novasep Process: Your Purification Specialist for Bio-Industries2关于诺华赛About NOVASEP2010 营业额: 3 亿欧元 (4.18亿美元)1200 员工, 其中研发人员超过2
2、00人2010 revenues: 300 M (USD 418 M) 1200 employees, 200 in R&D每年超过100个研发项目每年生产超过1000个活性分子全球有2000余套分离纯化系统Over 100 R&D projects per yearOver 100 active molecules produced per yearOver 2,000 purification systems installed worldwideNovasep Process: Your Purification Specialist for Bio-Industries3间歇色谱CHR
3、OMATO.蒸发精馏EVAPO.离子交换IEX膜过滤MF 分离分离纯纯化化PURIFICATION 结 晶 CRYSTALIZATION连续色谱SSMB诺华赛：全程分离纯化方案提供者Novasep: Purification Solution Provider 纯纯度度Purity原料制备化学合成和生物制造化学合成和生物制造BIOMANUFACTURING发酵细胞培养危险化学品手性化学品高能化合物电渗析ED4Producing by Fermentation挑战- 发酵产品的分离纯化Pure Product纯净产品Efficient Demineralization A Challenge F
4、or Fermentation Products高效脱盐针对发酵产品的挑战5Purification is often not economical !纯化过程常常不经济Pure Product纯净产品Efficient Demineralization A Challenge For Fermentation Products高效脱盐针对发酵产品的挑战Batch IEXDemineralization间歇式离交脱盐Crystallization结晶6How to improve your economics ?如何提高经济性?Pure Product纯净产品Efficient Deminer
5、alization A Challenge For Fermentation Products高效脱盐针对发酵产品的挑战Reduce These !减少这些!Increase This !提高这个!REDUCING CHEMICALS CONSUMPTION减少化学品消耗减少化学品消耗 Efficient Demineralization A Challenge For Fermentation Products高效脱盐针对发酵产品的挑战7Reducing Chemicals Consumption减少化学品消耗Select the right technology, according to
6、 your local conditions ! 根据根据实际实际工工艺艺状况状况,选择选择正确的脱正确的脱盐盐技技术术 Batch IEX 间歇离交 : low salt loads 低含盐量 Continuous IEX 连续离交: medium to high salt loads中-高含盐量 Electrodialysis 电渗析: medium to high salt loads, when electricity is cheap 中-高含盐量,且电较便宜 SSMB Chromatography 色谱: high to very high salt loads高-极高含盐量Whe
7、n using a resin based technology, select the most adapted resin, on a case to case basis ! 当采用基于当采用基于树树脂的技脂的技术时术时,需要基于特定的工需要基于特定的工艺环艺环境境,选择选择合适的合适的树树脂脂工工艺艺： ： Novasep has 200+ references of resins in portfolio ! 诺华赛已有200个以上个成功运用树脂的工程案例Efficient Demineralization A Challenge For Fermentation Products高
8、效脱盐针对发酵产品的挑战8Different Process Routes for Organic Acids针对有机酸的不同工艺路线Efficient Demineralization A Challenge For Fermentation Products高效脱盐针对发酵产品的挑战9Lysine purification案例： 赖氨酸连续离交纯化 1)CONTINUOUS (limited buffer tanks) 生产连续(缓冲罐减小)Feed and treated product 进进料罐和料罐和处处理后理后产产品罐品罐Chemicals and waste 化学品化学品储储罐和
9、罐和废废水罐水罐Reuse Water system 重用水系重用水系统统2)BETTER UTILITIES USAGE 公用工程的更好利用Less chemicals 更低的化学品消耗更低的化学品消耗Less water 更少的水耗更少的水耗Less effluents 更少的更少的废废水量水量3)LESS DILUTION DURING DISPLACEMENT (product or reagent) STEPS 置换环节减少稀释(生产或再生)More stable and high outlet product concentration 更更稳稳定更高的定更高的产产品品浓浓度度Le
10、ss water to evaporate 更少的蒸更少的蒸发发水量水量CONTINUOUS PROCESS ADVANTAGES 连续处理工艺的优势Continuous Ion Exchange vs DiscontinuousPrinciple & Advantages连续离交与非连续离交的对比CONTINUOUS PROCESS LIMITATIONS : 连续处理工艺的局限 Max linear velocity for proper adsorption / Elution 吸附吸附/洗脱洗脱时时需要更大的需要更大的线线速度速度Pressure drop considerations
11、 要注意要注意压压力降因素力降因素Typical Mass balance 1 System / 1 PeriodContinuous Ion Exchange applied to lysine purification连续离子交换在赖氨酸纯化中的应用Key Figures主要数据Key Performances Figures for Continuous Ion Exchange on Lysine purification赖氨赖氨酸酸纯纯化化连续连续离交系离交系统统的主要性能的主要性能参数参数* : Without taking into account backwashing seq
12、uence : 0,75 BV / period. Depending on pressure drop and suspended solids 没没有有计计入反洗水消耗：入反洗水消耗：约约0.75BV/周期，根据周期，根据压压力降及力降及悬悬浮物浮物变变化化Resin Loading 树树脂脂负载负载量量180 g Lys / liter resin - Minimum Recovery 收率收率98.5 % - Minimum Lysine Concentration in RC 赖氨酸浓度赖氨酸浓度195 g Lys / L +/- 15g/LLysine capture during
13、 adsorption吸附吸附环节赖氨环节赖氨酸捕酸捕获获率率99 %Water consumption *水耗水耗1,8 BV / PeriodH2SO4 98% consumption98%浓浓度硫酸消耗度硫酸消耗 97% 色谱技术用于柠檬酸生产：收率97% - Purity 98% 纯度=98%, Citric Acid Gypsum free process 柠檬酸无石膏生产工艺 6 industrial references. 柠檬酸: 6套工业生产装置在欧州/北美及亚州成熟运行 2 start-ups in 2012. 另外2套大规模工业扩产装置将于2012年投产.Efficient Demineralization A Challenge For Fermentation Products高效分离针对发酵产品的挑战2425诺华赛中国客户分布诺华赛中国客户分布NOVASEP, WE BRING VALUE TO OUR CLIENTS BY CONTINUOUS INNOVATIONS!诺华赛诺华赛： ： 通通过过持持续续的技的技术创术创新新为为客客户户提供价提供价值值！Novasep Process: Your Purification Specialist for Bio-Industries26
