1、L/O/G/O乳腺癌五年或更长期的辅助内分泌治疗：乳腺癌五年或更长期的辅助内分泌治疗：一项已发表的随机试验的一项已发表的随机试验的metameta分析分析Fausto PetrelliBreast Cancer Res Treat 2013-6-281一、背景介绍一、背景介绍230%40%一、背景介绍一、背景介绍3 12000BC 5年年VS10年年TAM治疗治疗中位随访中位随访13.6年：减少总生存及晚期年：减少总生存及晚期BC发生发生子宫内膜癌发生风险子宫内膜癌发生风险(3.1 vs.1.6%),死亡风险增加死亡风险增加0.2%。10年年TAM，减少，减少BC复发风险复发风险(P=0.00
2、3),BC 相相关死亡风险关死亡风险(P=0.05)，整体死亡风险，整体死亡风险(P=0.1),第九年后的获益更大。第九年后的获益更大。5年年TAM 来曲唑来曲唑/安慰剂，安慰剂，64个月的中位随访中，个月的中位随访中，显著降低复发风险，但显著降低复发风险，但OS相近。相近。考虑了揭盲后，安慰剂组中考虑了揭盲后，安慰剂组中66%应用了来曲唑，提应用了来曲唑，提示来曲唑显著提高了示来曲唑显著提高了DFS和和OS。二、研究方法二、研究方法 1.数据来源4电子搜索二、研究方法二、研究方法 2.研究选择/数据提取5入选标准入选标准提取数据提取数据早期乳腺癌患者早期乳腺癌患者RCT:比较比较5年及更久内
3、分泌治年及更久内分泌治疗疗开始开始2013-6-11研究由两名研究人员分别选择，出现分歧时有第三名研究人员评议。研究由两名研究人员分别选择，出现分歧时有第三名研究人员评议。英文发表英文发表基本信息：杂志名、发表年份、作者名基本信息：杂志名、发表年份、作者名人口统计学：中位年龄、淋巴结水平、人口统计学：中位年龄、淋巴结水平、月经状态、原发肿瘤的激素水平月经状态、原发肿瘤的激素水平研究信息：样本量、研究设计、研究终点研究信息：样本量、研究设计、研究终点治疗方案治疗方案结果结果（率或事件数）：（率或事件数）：OS,无复发生存无复发生存(RFS),乳腺癌相关生存乳腺癌相关生存(BCSS),非癌症相关非
4、癌症相关死亡死亡,局部或远处的局部或远处的 RFS(LR-RFS/D-RFS)人类研究人类研究二、研究方法二、研究方法6三、结果三、结果7三、结果三、结果8三、结果三、结果9三、结果三、结果10三、结果三、结果11ER+三、结果三、结果12两组中相似36%，P=0.0213%，P=0.02三、结果三、结果13四、讨论四、讨论 1、14Click to edit title styleThemeGallery is a Design Digital Content&Contents mall developed by Guild Design Inc.Add your textAdd your
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