1、2021/7/261(最新整理)第三章抗体2021/7/2622021/7/263Emil von Behring(1845-1917)antibody是介导体液免疫的重要是介导体液免疫的重要效应分子,是效应分子,是B细胞接细胞接受抗原刺激后增殖分化受抗原刺激后增殖分化为浆细胞所产生的糖蛋为浆细胞所产生的糖蛋白。白。German physiologist.He won a1901 Nobel Prize for work on serum immunization against diphtheria and tetanus.2021/7/2642021/7/2652021/7/2662021
2、/7/267血清电泳图形其中血清电泳图形其中A:正常血清:正常血清 B:免疫血清(抗血清):免疫血清(抗血清)免疫血清经相应抗原吸收,再电泳后,其图形则变为免疫血清经相应抗原吸收,再电泳后,其图形则变为A2021/7/2682021/7/2692021/7/26102021/7/26112021/7/26122021/7/26132021/7/26142021/7/26152021/7/2616(1)(1)类类2021/7/26172021/7/26182021/7/26192021/7/26202021/7/26212021/7/26222021/7/26232021/7/26242021/
3、7/26252021/7/26262021/7/26272021/7/26282021/7/26292021/7/26302021/7/26312021/7/26322021/7/2633与抗原特异性结合的部位与抗原特异性结合的部位某些同种异型遗传标记某些同种异型遗传标记结合补体结合补体结合结合FcR2021/7/26342021/7/26352021/7/26362021/7/26372021/7/26382021/7/26392021/7/26402021/7/26412021/7/26422021/7/26432021/7/26442021/7/26452021/7/26462021/7
4、/26472021/7/26482021/7/26492021/7/26502021/7/26512021/7/26522021/7/26532021/7/26542021/7/2655第二节第二节 免疫球蛋白的血清型免疫球蛋白的血清型2021/7/2656免疫球蛋白具有异质性免疫球蛋白具有异质性2021/7/26572021/7/26582021/7/26592021/7/26602021/7/26612021/7/26622021/7/26632021/7/26642021/7/26652021/7/26662021/7/26672021/7/26682021/7/26692021/7/2
5、6702021/7/26712021/7/26722021/7/26732021/7/26742021/7/26752021/7/26762021/7/26772021/7/26782021/7/26792021/7/26802021/7/26812021/7/26822021/7/26832021/7/26842021/7/26852021/7/26862021/7/26872021/7/26882021/7/26892021/7/26902021/7/26912021/7/26922021/7/26932021/7/26942021/7/26952021/7/2696IgE的特性和功能的特
6、性和功能2021/7/2697IgD的特性和功能 血清中含量低(血清中含量低(1%),其生物学作用尚不清楚),其生物学作用尚不清楚 mIgD可作为可作为B细胞分化成熟标记,成熟细胞分化成熟标记,成熟B细胞同时表达细胞同时表达mIgM和和mIgD mIgMmIgD成熟成熟B细胞细胞活化活化B细胞细胞未成熟未成熟B细胞细胞2021/7/26982021/7/26992021/7/261002021/7/261012021/7/261022021/7/261032021/7/26104VHDJ/200134CHJ/Vk k754JVl l2Cl lVl lJCl l2Ck kCl lMouse antibody genes2021/7/261052021/7/261062021/7/261072021/7/261082021/7/26109多克隆抗体多克隆抗体(polyclonal antibody)2021/7/26110带有多个表位带有多个表位抗原抗原针对不同表位的针对不同表位的B细胞细胞克隆增殖克隆增殖多种抗体的混合物多种抗体的混合物(多克隆抗体)(多克隆抗体)刺激小鼠刺激小鼠2021/7/261112021/7/261122021/7/261132021/7/261142021/7/26115