1、Lesson ThirteenImmune System Anatomic Receptor Nomenclature Precursor Thymus Naive Progeny Quiescent Humoral Mononuclear Phagocyte Dendritic Follicular Hematopoietic Residence Architecture Cytokines Langerhans cell Gastrointestinal Tonsil Recruit Microbial Vascular endothelial cells The anatomic org
2、anization of the cells and tissues of the immune system is of critical importance for the generation of immune responses.This organization permits the small number of lymphocytes specific for any one antigen to locate and respond effectively to that antigen regardless of where in the body the antige
3、n is introduced.Text The adaptive immune response depends on antigen-specific lymphocytes,accessory cells required for lymphocyte activation,and effector cells that eliminate antigens.B and T lymphocytes express highly diverse and specific antigen receptors and are the cells responsible for the spec
4、ificity and memory of adaptive immune responses.Natural killer(NK)cells are a distinct class of lymphocytes that do not express highly diverse antigen receptors and whose functions are largely in innate immunity.Many surface molecules are differentially expressed on different subsets of lymphocytes,
5、as well as on other leukocytes,and these are named according to the CD nomenclature.Both B and T lymphocytes arise from a common precursor in the bone marrow.B cell development proceeds in the bone marrow,whereas T cell precursors migrate to and mature in the thymus.After maturing,B and T cells leav
6、e the bone marrow and thymus,enter the circulation,and populate peripheral lymphoid organs.Nave B and T cells are mature lymphocytes that have not been stimulated by antigen to become differentiated lymphocytes.When they encounter antigen,they differentiate into effector lymphocytes that have functi
7、ons in protective immune responses.Effector B lymphocytes are antibody-secreting plasma cells.Effector T cells include cytokine-secreting CD4+helper T cells and CD8+cytolytic(or cytotoxic)T lymphocytes(CTLs).Some of the progeny of antigen-activated B and T lymphocytes differentiate into memory cells
8、 that survive for long time periods in a quiescent state.These memory cells are responsible for the rapid and enhanced responses to subsequent exposures to antigen.Accessory cells function to promote the activation of lymphocytes and to perform effector functions that may be enhanced by humoral or c
9、ell-mediated adaptive immune responses.Accessory cells include mononuclear phagocytes,dendritic cells,and follicular dendritic cells.The organs of the immune system may be divided into the generative organs(bone marrow and thymus),where lymphocytes mature,and the peripheral organs(lymph nodes and sp
10、leen),where nave lymphocytes are activated by antigens.Bone marrow contains the stem cells for all hematopoietic and lymphoid cells and is the site of maturation of all of these cell types except T cells.The lymph nodes are the sites where B and T cells respond to antigens that are collected by the
11、lymph draining peripheral tissues.Lymphocytes in the spleen respond to blood-borne antigens.Both lymph nodes and spleen are organized into B cell areas(follicles)and T cell areas(parafollicular zones).The T cell areas are also the sites of residence of mature dendritic cells,which are accessory cell
12、s specialized for the activation of nave T cells.Follicular dendritic cells reside in the B cell areas and serve to activate B cells during humoral immune responses to protein antigens.The development of secondary lymphoid tissue architecture depends on cytokines.The cutaneous immune system consists
13、 of specialized collections of accessory cells and lymphocytes adapted to respond to environmental antigens encountered in the skin.A network of immature dendritic cells called Langerhans cells is present in the epidermis of the skin that serves to trap antigens and then transport them to draining l
14、ymph nodes.The mucosal immune system includes specialized collections of lymphocytes and accessory cells organized to optimize encounter with environmental antigens introduced through the respiratory and gastrointestinal and genitourinary tracts.Peyers patches in the intestinal wall and the tonsils
15、in the oropharynx are examples of mucosal immune system tissue.Lymphocyte recirculation is the process by which lymphocytes continuously move between sites throughout the body through blood and lymphatics,and it is critical for the initiation and effector phases of immune responses.Nave T cells norm
16、ally recirculate among the various peripheral lymphoid organs,increasing the likelihood of encounter with antigen displayed by antigen-presenting cells such as mature dendritic cells.Memory and effector T cells more typically are recruited to peripheral sites of inflammation where microbial antigens are located
