1、Liu BaochiShanghai Public Health Clinical Center affiliated to Fudan UniversityTreating patients with liver cirrhosis by BMT第1页，共17页。Decompensated liver cirrhosis is difficult to cureliver cirrhosis with AIDS is more difficult to give effective treatmentStem cell treatment bring the hope for the pat
2、ients of AIDS with decompensated liver cirrhosis.BACKGROUND第2页，共17页。7 AIDS patients with decompensated liver cirrhosis and portal ven hypertention,ascites,internal blooding were investigated.Patients 第3页，共17页。Splenectomy were performed in 7 AIDS patients with liver cirrhosis to alleviate portal vein
3、 hypertention and avoid internal blooding.Methods 第4页，共17页。During the surgical procedure,a catheter was placed in the superior mesenteric vein in preparation for bone marrow transfusion(BMT).第5页，共17页。20mL bone marrow was aspirated by puncture of the iliac crest one week after surgery and transfused
4、through the attached catheter into the portal vein.Methods 第6页，共17页。Methods One or two doses of BMT were performed on each patient at a one month interval.第7页，共17页。Results Except diminishment of ascites and recovery of serum albumin levels,total white blood cells and platelet count was also signific
5、antly improved.Unexpectedly,one month after BMT,CD4+T cell count in peripheral blood of all 7 patients began to increase significantly.第8页，共17页。age before1month3month12month24month56 618126934151236 80120366519541322741 130 265 141244289235411999326612111277663611263539 303 49186476810871127age befo
6、re1month3month12month24month56 22831836851282536 529621686648796322741 256 324 3123626494624181886542478189296863918963539 174 68026982614862327changes of CD4+T lymph cell(/ul)changes of CD8+T lymph cell(/ul)第9页，共17页。age before1month3month12month24month56 30.834.134.638.640.136 33.535.636.838.838.93
7、22741 27.4 36.3 31.338.236.828.637.938.634.238.139.638.238.841.13539 37 34.139.438.436.339.2age before1month3month12month24month56 12.913.616416.115,236 48.238.631.628.426.4322741 56.9 16.7 57.538.918.965.532.418.142.626.817.931.531.616.63539 21.8 19.219.216.48.514.2changes of albumin（g/L）changes of
8、 Tbl（umol/L）第10页，共17页。age before1month3month12month24month55 2.16.6545.16,236 1.897.66.66.45.4322741 2.14 2 2.543.98.911.45.47.18.65.86.97.65.66.53539 3.35 5.555.15.47.46.4age before1month3month12month24month55 36306286254.626836 26.7296326.4284246322741 101 56 28412419177346427286264.63102882892893
9、539 16 133153312187342changes of WBC（109/L）changes of Plate（109/L）第11页，共17页。age before1month3month12month24month55 10710911412613236 88.6102.6129132112322741 63.3 55 8789.494.21091211181121311211181341283539 125 601308811996age before1month3month12month24month56 1715.21414.213.636 19.114.813.61414.1
10、322741 17.9 18.3 22.11614.117.914.414.616.213.814.214.414.214.13539 19.1 17.114.615.814.314.9changes of Hb（g/L）changes of PT(秒)第12页，共17页。第13页，共17页。liver cirrhosis and highly enlarged spleen with huge amout of ascites before operationfour months after operation and BMT.Ascites disappeared and liver enlarged第14页，共17页。It may change the standard of liver transplantationClinical significance of BMT第15页，共17页。BMT for the AIDS patient with liver cirrhosis can promote liver function and immune reconstruction.Conclusion第16页，共17页。第17页，共17页。
