1、急性肾炎专题知识讲座急性肾炎专题知识讲座Edema 急性肾炎专题知识讲座2Hematuria急性肾炎专题知识讲座3 Hypertension Convulsion Anti o C3 proteinuria 急性肾炎专题知识讲座4 This glomerulus is hypercellular and capillary loops are poorly defined.This is a type of proliferative glomerulonephritis急性肾炎专题知识讲座5 the immune deposits are distributed in the capilla
2、ry loops in a granular,bumpy pattern because of the focal nature of the deposition process急性肾炎专题知识讲座6Diagonosis?Why?edema proteinuria Hematuria hypertension.急性肾炎专题知识讲座7Background Atypical onset edema hematuria proteinuria hypertension Persistently depressed C3(past 8-10 wk)急性肾炎专题知识讲座9急性肾炎专题知识讲座10Pat
3、hophysiology and Clinical manifestation急性肾炎专题知识讲座11streptococcal antigens specific antibodies activate the complement system c3 急性肾炎专题知识讲座12急性肾炎专题知识讲座13Various cytokines other cellular immunity factors glomerular basement membrane blood efusion Hematuria Proteinuria cast急性肾炎专题知识讲座14急性肾炎专题知识讲座15 Vari
4、ous cytokines proliferation of mesangial and epithelial cells glomerular perfusion,glomerular filtrate(GF)-Severe oliguria,renal failure急性肾炎专题知识讲座16急性肾炎专题知识讲座17 glomerular filtrate(GF)-H2O,Na+sterve -blood volume edema hypertention circulatory congestion encephalopathy.急性肾炎专题知识讲座18Pathology The hype
5、rcellularity of post-streptococcal glomerulonephritis is due to increased numbers of epithelial,endothelial,and mesangial cells as well as neutrophils in and around the capillary loops.This disease may follow several weeks after infection with certain strains of group A beta hemolytic streptococci.急
6、性肾炎专题知识讲座19 Post-streptococcal glomerulonephritis is immunologically mediated,and the immune deposits are distributed in the capillary loops in a granular,bumpy pattern because of the focal nature of the deposition process.急性肾炎专题知识讲座20Clinical manifestion Sex Age History Gross hematuria edema Hypertension 急性肾炎专题知识讲座211 Circulatory congestion2 Hypertensive encephalopathy 3 Acute renal failure 急性肾炎专题知识讲座22
