1、血管性认知功能障碍 涵盖所有由脑血管病引起的认知损害类型及其临床表现 包括不同程度痴呆、CIND和广义的MCI （非遗忘型）的一部分 突破痴呆定义局限，发现更多可预防及可治疗的认知功能损害 早期干预危险因素，降低痴呆发病率 ADVD 13N-NH3 PET 18F-FDG PET CT Head trauma Epilepsy Cerebrovascular accidents High LDL-cholesterol Low HDL-cholesterol Diabetes mellitus Atrial fibrillation Arterial hypertension High hom
2、ocystein levels Parkinsons disease Thyroid diseases Malnutrition No intake of NSAD No intake of H2-antagonists No intake of statins Genetic polymorphisms:APO-E 4.Cerebral understimulation Depression Low intelligence Low education Illiteracy Secondary hearing loss Mental inactivity-Physical inactivit
3、y.Demographic variables Low social class High number of siblings Childhood rural residence Dominant spouse Low self-esteem Female gender?.社会人口学因子社会人口学因子 年龄、性别（男）、种族、教育年龄、性别（男）、种族、教育 家族史家族史 遗传遗传 CADASIL APO 4 Dutch型型AD遗传脑出血伴淀粉样变遗传脑出血伴淀粉样变高血压高血压卒中和卒中和TIA史史心脏病心脏病血压低血压低控制危险因素预防血管性痴呆 AD MMSE score0years
4、from diagnosis+4+8-8-4010 2030normal cognitionAdapted from:Petersen et al.,Arch Neurol.58:1985-1992,2001;Linn et al.,Arch Neurol 53:485-490,1995;Wahlund et al.,Neurobiol Aging 17,suppl 4:S 147,1996;Johansson&Zarit,Int J Geriatr Psychiatry 12:53-59,1997 MCIdementialoss of independent livingAAMI/ARCDcognitive performanceLow
