1、 Primary intracranial tumor:Glioma 胶质瘤（胶质瘤（40%）Meningioma 脑膜瘤（脑膜瘤（15%）Acoustic neurinoma 听神经瘤（听神经瘤（8%）Metastatic tumors:lung,breast 6 Tumors分类分类发病率发病率children:glioma,medulloblastoma 髓母细胞瘤髓母细胞瘤 Size,location nature Local effect General effect特点特点影响 Biologic histologic malignancy Invasion Metastasistu
2、morDifferentiation分化分化Clinical progressionGenetic changesI.Astrocytoma 星形细胞瘤星形细胞瘤AstrocytomaAnaplastic astrocytoma间变性间变性-Glioblastoma multiforme多形性胶质母细胞瘤多形性胶质母细胞瘤atypiaatypia,mitotic rate,mitotic rate,capillary,endothelial cells,capillary,endothelial cells,necrosis,hemorrhagenecrosis,hemorrhageAstro
3、cytomaAnaplastic astrocytomaGlioblastomamultiformepoorly definedgray-whitesolidmultiform 多形性多形性:cyst,necrosis,hemorrhageAstrocytona病变病变P53 mutation/loss of chr.17pLoss of chr.22qRb mutation/loss of chr.13qP16 deletion/loss of chr.3pLoss of chr.19qLoss of ch.10EGFR gene amplificationGenetic changes i
4、n astrocytomaNormal astrocyteAstrocytomaAnaplastic astrocytomaGlioblaxtomamultiformeGlioblatona multiformemultiformemultiforme 20y Cerebellum Primitive undifferentiated cell small tumor cells,scanty cytoplasm rosette 菊形团菊形团 Seeding through CSF Highly malignantII.Medulloblastoma 髓母细胞瘤髓母细胞瘤 Seeding of
5、 medulloblastoma From:arachnoid cell 蛛网膜细胞蛛网膜细胞 部位部位 :arachnoid granulation dura 硬脑膜硬脑膜 大体：大体：solid,gritty 砂粒样砂粒样 光镜：光镜：whorl-like pattern psammoma砂粒体砂粒体 Malignant:rareIII.Meningioma 脑膜瘤脑膜瘤医学课件园 Here is another benign meningioma beneath the dura.These neoplasms are slow growing,but may reach a large size before symptoms lead to detection.From:Schwann cell 大体大体:encapsulated,solitary nerves,spinal roots 光镜光镜:Spindle tumor cells,排列成排列成 束状，网状束状，网状 BenignIV.Neurilemmoma 神经鞘瘤神经鞘瘤SchwannomaInflammation Tumor Trauma .Edema Hydrocephalus IIPherniation
