1、 TOF Ratio0,40,50,60,70,80,91,0Per centof control20406080100FEV1FIV1 Berg,Viby-Mogensen Acta Anaesth Scand 1997;41:1095-1103 罗库溴铵诱导剂量后,待T1恢复到10%开始罗库溴铵的靶控输注 血浆靶浓度为2g/ml,维持肌松T1%10%手术结束前10min停止输注罗库溴铵食道括约肌张力与TOFr的相关比较Eriksson LI et al Anesthesiology 1997;87:1035-1043050100150ControlTOF 0.6TOF 0.7TOF 0.8
2、TOF 0.9*TOF-ratio吞咽困难baseline6%0.628%*0.717%*0.820%*0.913%*p0.05 vs.baseline小 结 Sundman et al Anesthesiology 2000;92:977 70 60 50 40 30 20 10 0 120min n=23 n=101 n=164 n=238v在单次注入中效肌松药并不进行拮抗的情况下,即使在2小时以上,发生残余神经肌肉阻滞仍较普遍。v客观测定神经肌肉传递功能是诊断残余神经肌肉阻滞的较可靠方法。拮 抗Kopman AF,Antagonism of cisatracurium and ocuronium block at a tactile train-of-four count of 2:should quantitative assessment of neuromuscular function be mandatory?Anesth Analg.2004;98(1):102 拮抗的缺点 谢 谢