1、2020-12-08肺动脉漂浮导管PAC（新课件）1肺动脉漂浮导管PAC2020-12-08肺动脉漂浮导管PAC（新课件）2ContentsIntroductionPAC Placement Hemodynamic MonitoringControversy on PAC Parameter integrationCases Discussion2020-12-08肺动脉漂浮导管PAC（新课件）3 What is Pulmonary Artery Catheter?Full name:Swan-Ganz Catheter Used it to monitor a patients hemody
2、namics when we cant answer the question using noninvasive/clinical measures 2020-12-08肺动脉漂浮导管PAC（新课件）4Clinical use of the PAC（Diagnosis）Differentiation among causes of shock Cardiogenic Hypovolemic Distributive(sepsis)Obstructive(massive pulmonary embolism)Differentiation of pulmonary edema Cardioge
3、nic Noncardiogenic Evaluation of pulmonary hypertensionDiagnosis of left-to-right intracardiac shunt Diagnosis of pericardial tamponade 2020-12-08肺动脉漂浮导管PAC（新课件）5Clinical use of the PAC（Therapy）Management of perioperative patient with unstable cardiac status Management of complicated myocardial infa
4、rction Management of severe preeclampsia Guide to pharmacologic therapy Vasopressors；Inotropes；VasodilatorsGuide to nonpharmacologic therapy Fluid management；Burns ；Renal failure；Sepsis；Heart failure；Decompensated cirrhosis Ventilator management Assessment of best PEEP for DO22020-12-08肺动脉漂浮导管PAC（新课
5、件）6ContentsIntroductionPAC Placement Hemodynamic MonitoringControversy on PAC Parameter integrationCases Discussion2020-12-08肺动脉漂浮导管PAC（新课件）7Structure of PAC2020-12-08肺动脉漂浮导管PAC（新课件）8PAC2020-12-08肺动脉漂浮导管PAC（新课件）9首选：右颈内静脉首选：右颈内静脉2020-12-08肺动脉漂浮导管PAC（新课件）10Comparison among PA catheter insertion sites2
6、020-12-08肺动脉漂浮导管PAC（新课件）11PAC insertion Right internal jugular vein Shortest and straightest path to the heart Left subclavian Does not require the PAC to pass and course at an acute angle to enter the SVC Femoral veins Distant sites Passing a PAC into the heart can be difficult Fluoroscopic assista
7、nce may be necessary Compressible and preferable if the risk of hemorrhage is high2020-12-08肺动脉漂浮导管PAC（新课件）12PAC insertion After inserting the PAC as far as the 20cm mark，the balloon is inflated with air.Inflation should be slow and controlled(1 mL/s)and should not surpass the recommended volume(1.5
8、 mL).Always inflate the balloon before advancing the PAC and always deflate the balloon before withdrawing the PAC.CRX：check the position of the PAC PA diastolic pressure PAWP 2020-12-08肺动脉漂浮导管PAC（新课件）13PAC on CRX（PA）2020-12-08肺动脉漂浮导管PAC（新课件）14Placement of the catheter2020-12-08肺动脉漂浮导管PAC（新课件）15Righ
9、t Atrium20 cmNormal right atrial presssure is 0-6cmHg.Normal oxygen content 15%（ml/dL)Normal O2 saturation 75%2020-12-08肺动脉漂浮导管PAC（新课件）16Waveforms of CVP2020-12-08肺动脉漂浮导管PAC（新课件）17EKG-RAPEKG Mechanical event RAP80 100 milliseconds after P wave RA systolea wave RA diastole x descent After QRS Tricusp
10、id valve closure c wave After peak of T wave RA filling/tricuspid valve closed v wave RA emptying at opening of tricuspid valve/onset of right ventricle diastole y descent 2020-12-08肺动脉漂浮导管PAC（新课件）18Right Atrium2020-12-08肺动脉漂浮导管PAC（新课件）19 Right ventricular waveformRV systolic=17-30cmHgRV diastolic=0
11、-6cmHgRV O2 content=15%（ml/dL)RV O2 saturation 75%2020-12-08肺动脉漂浮导管PAC（新课件）20 Pulmonary artery waveformNormal PA pressure,systolic 15-30Normal PA pressure,diastolic 5-13O2 content 15%（ml/dL)O2 saturation 75%2020-12-08肺动脉漂浮导管PAC（新课件）21EKG-PAPEKG Mechanical event PAPT waveRight ventricle ejection of b
12、lood into pulmonary vasculatureSystolic PAS 15 30 mm Hg80 milliseconds after onset of QRS Indirect indicator of LVEDPEnd-diastolic(PAEDP 8 12 mm Hg)Mean(9 18 mm Hg)PAS:pulmonary artery systolicLVEDP:left ventricular end-diastolic pressurePAEDP:pulmonary artery end-diastolic pressure2020-12-08肺动脉漂浮导管
13、PAC（新课件）22Pulmonary artery waveform2020-12-08肺动脉漂浮导管PAC（新课件）23 PAWP waveform2020-12-08肺动脉漂浮导管PAC（新课件）24PAWP waveform2020-12-08肺动脉漂浮导管PAC（新课件）25EKG-PAWPEKG Mechanical event PAWPAligned with the end of the QRS Left atrial(LA)systole a wave LA diastole x descent T-P interval LA filling/mitral valve clo
14、sedv wave LA emptying at opening of mitral valve/onset of left ventricle diastoley descent 2020-12-08肺动脉漂浮导管PAC（新课件）26PAWP waveform2020-12-08肺动脉漂浮导管PAC（新课件）27ECG-CVP-PAWP2020-12-08肺动脉漂浮导管PAC（新课件）28 How do u know u r in Zone 3？v Catheter should be below the left atrium on CRXv If there is marked resp
15、iratory vairation in the PAWP tracing you are likely not in Zone 3v If PAD PAWP then you are likely not in Zone 32020-12-08肺动脉漂浮导管PAC（新课件）29Rapid Flush Test（方波试验）2020-12-08肺动脉漂浮导管PAC（新课件）30 Phlebostatic Axis2020-12-08肺动脉漂浮导管PAC（新课件）31PACPAC并发症、可能原因、预防及处理并发症、可能原因、预防及处理并发症可能原因预防处理心律失常没有保护的导管尖在心内膜移动导管在
16、右房或右室内形成多余环操作导管太多，时间太长前送导管时保持气囊充气，轻盈前送射胸片以最少的操作快速、轻柔插入导管必要时使用利多卡因，发生室颤立即除颤回撤导管消除多余环血栓/栓塞导管周围纤维性管套形成形成血栓导管内血栓导管阻塞肺动脉分支使用肝素浸泡的导管使用带侧壁的套管滴注肝素肝素盐水持续冲洗，4-6 小时手工冲洗一次高危病人全身抗凝保持导管尖位于主肺动脉抗凝，可能时溶栓肺梗塞/肺动脉破裂导管尖向远端移位（尤其在头 24 小时）导管嵌顿时间过长导管血栓栓塞导管放好后即刻或 24 小时后拍胸片，消除右房或右室内导管环持续监测肺动脉波形短期嵌顿（30 秒，用 PAEDP 代替 PAWP使用肝素浸泡过
17、的导管，用肝素液适当冲洗回撤导管尖至肺动脉加强护理必要时手术修复2020-12-08肺动脉漂浮导管PAC（新课件）32PACPAC并发症、可能原因、预防及处理并发症、可能原因、预防及处理并发症可能原因预防处理感染插入导管、安装设备、取血标本或交换导管时感染严格无菌操作所有三通均套上无菌帽在导管上使用无菌袖套使用前检查换能器顶盖，不反复使用一次性顶盖更换病人时消毒换能器除颤后更换换能器顶盖不要在换能器内使用 5%糖液或用之作冲洗液操作时间太长每 48 小时更换所有设备每天观察伤口并消毒减少导管放置时间每天在插管部位涂抹碘酊，加盖无菌敷料近早拔出导管（必要时 4 天更换一次）心脏填塞导管尖造成穿孔
18、轻柔操作在气囊充气下送管预阻力决不能前送导管心包穿刺逆转肝素作用导管打圈或打结右房或右室扩大插管时间太长操作较多至导管变软使用小号（5F）导管在软化前轻送导管，用冰盐水冲洗导管或插入导引钢丝更换新导管气囊破裂过度充气用液体充盈气囊回抽注射器主动放气监测 PAEDP 而不是 PAWP减少嵌顿次数按导管注明的数量充盈气囊使用空气或 CO2 充盈气囊通过撤走注射器让空气自动逸出气囊2020-12-08肺动脉漂浮导管PAC（新课件）33ContentsIntroductionPAC Placement Hemodynamic MonitoringControversy on PAC Parameter
19、 integration2020-12-08肺动脉漂浮导管PAC（新课件）34 Hemodynamic values of normal adults2020-12-08肺动脉漂浮导管PAC（新课件）35Hemodynamic MonitoringCO CI SV SVIRAP(CVP)PAP PAWPCardiac outputPressureSvO22020-12-08肺动脉漂浮导管PAC（新课件）36 Cardiac Output（CO）定义：在1min内从心室射 出的血液总量公式：CO=HR x SVCO=48 L/min2020-12-08肺动脉漂浮导管PAC（新课件）37Cardi
20、ac Output Index（CI）CI CO/BSA 正常值:2.8 4.2 L/min/m2 CI更能体现患者的个体差异性2020-12-08肺动脉漂浮导管PAC（新课件）38每搏量每搏量(SV)与与 每搏量指数每搏量指数(SVI)SV定义：每次心跳所射出的血液量SV=CO/HR SV正常值：50-110ml/beatSVISV/BSA SVI正常值：30-65ml/m2/beat2020-12-08肺动脉漂浮导管PAC（新课件）39What Elevates the Right Atrial Pressure?RV infarct Pulmonary hypertension Pulm
21、onary stenosis Left to right shunt Tricuspid valvular disease Left heart failure2020-12-08肺动脉漂浮导管PAC（新课件）40Prominent RA pulsationsProminent a wave:Tricuspid stenosisCannon a wave:AV dissociation Ventricular tachycardiaProminent v wave:Tricuspid regurgitation or VSD2020-12-08肺动脉漂浮导管PAC（新课件）41What Inc
22、reases RV Pressures?RV failure Pulmonary hypertension Pulmonary stenosis Pulmonary Embolism Cardiomyopathy Cardiac tamponade Cardiac constriction2020-12-08肺动脉漂浮导管PAC（新课件）42What Elevates PA pressure?Volume Overload(backflow)Primary lung disease Primary pulmonary hypertension Pulmonary Embolism Left t
23、o right shunt Mitral Valve Disease2020-12-08肺动脉漂浮导管PAC（新课件）43用压力推测心室舒张末期容量的前提用压力推测心室舒张末期容量的前提 导管位置导管位置 无二尖瓣无二尖瓣 心室顺应性心室顺应性 正确正确 疾病疾病 正常正常 PAWP LAP LVEDP LVEDV Preload2020-12-08肺动脉漂浮导管PAC（新课件）44PAWP and LVEDP may be discordantConditions in which PAWPLVEDP Mitral stenosis Mitral valve regurgitation Le
24、ft atrial myxoma Pulmonary embolus Conditions in which PAWP25 mmHg)LVEDP2020-12-08肺动脉漂浮导管PAC（新课件）45Systemic and pulmonary vascular resistance80*(MPAP-LAP)/肺血流量80*(MAP-RAP)/COR=U/IPVRSVR欧姆定理欧姆定理2020-12-08肺动脉漂浮导管PAC（新课件）46Systemic Vascular ResistanceCauses of SVRVolume infusionsHypovolemiaLow CO state
25、sLV failureHypothermiaVasopressorsIncreased blood viscosityCauses of SVRDiureticsSepsisVasodilatorsPeripheral vasodilationLoss of vasomotor tone2020-12-08肺动脉漂浮导管PAC（新课件）47Pulmonary Vascular ResistanceCauses of PVRHypoxiaPEEPPulmonary edemaPulmonary hypertensionARDSPulmonary emboliValvular heart dise
26、aseCongenital heart defectsCauses of PVRVasodilator therapyProstaglandinsCorrection of hypoxiaProstacyclin（依前列醇）2020-12-08肺动脉漂浮导管PAC（新课件）48SvO22020-12-08肺动脉漂浮导管PAC（新课件）49ContentsIntroductionPAC Placement Hemodynamic MonitoringControversy on PAC Parameter integrationCases Discussion2020-12-08肺动脉漂浮导管P
27、AC（新课件）502020-12-08肺动脉漂浮导管PAC（新课件）512020-12-08肺动脉漂浮导管PAC（新课件）522020-12-08肺动脉漂浮导管PAC（新课件）53PAC为何不能改善预后？问问题题何何在在12345不恰当的适应症不恰当的适应症PAC相关的并发症相关的并发症数据的可靠性数据的可靠性不恰当的治疗不恰当的治疗数据解读的准确性数据解读的准确性2020-12-08肺动脉漂浮导管PAC（新课件）54We still need PAC？2020-12-08肺动脉漂浮导管PAC（新课件）55到底是谁的问题？Iberti et al(JAMA 1990)美国和加拿大13家医院 4
28、96MD 47的受试者对PAC不能作出正确回答 Gnaegi A et al (CCM1997)134个ICU的535 MD 68的医生所具有的知识不能满足PAC使用Squara P et al(Chest 2002)仅有38的医生按照给出的PAC数据选择了正确的治 疗方案，但仍有多达35的医师选择了错误的治疗方案2020-12-08肺动脉漂浮导管PAC（新课件）56临床评价 VS 血流动力学 103例PAC 医生在置管前对血流动力学指标的范围及治疗方案进行预测 预测准确性：PAWP 30%；CO SVR RAP 50%留置PAC后：治疗计划需要重新修正 58%应用未预计到的治疗 30%结论：
29、1 单纯根据临床评价难以准确预测血流动力学指标 2 PAC监测将改变治疗策略Crit Care Med.1984 Jul;12(7):549-53.2020-12-08肺动脉漂浮导管PAC（新课件）57Benefit or Harm？2020-12-08肺动脉漂浮导管PAC（新课件）58能否替代PAC？可以替代可以替代心输出量参数心输出量参数不可替代不可替代压力参数压力参数SCVO2近似替代近似替代SVO22020-12-08肺动脉漂浮导管PAC（新课件）59ContentsIntroductionPAC Placement Hemodynamic MonitoringControversy
30、on PAC Parameter integrationCases Discussion2020-12-08肺动脉漂浮导管PAC（新课件）60PAC要回答的四个问题2020-12-08肺动脉漂浮导管PAC（新课件）61PAC参数整合：前负荷 CVP（RAP）/PAWP Any given level of filling pressure:not reliable！Static markers of cardiac preload fail to predict volume responsiveness Fluid challnge CVP 2-5 rule PAWP 3-7 rule CO
31、/CI/SV 10%2020-12-08肺动脉漂浮导管PAC（新课件）62PAC参数整合：后负荷v左室射血的阻抗及外左室射血的阻抗及外 周阻力周阻力v SAP MAP SVR后负荷后负荷v右室射血的阻抗及外右室射血的阻抗及外 周阻力周阻力v PAP MPAP PVR2020-12-08肺动脉漂浮导管PAC（新课件）63PAC参数整合：心脏收缩力 CO并不是心脏射血功能的可靠指标 每搏输出量（SV）/每搏指数（SVI）SV/SVI增加的原因：代偿；SVR下降 SV/SVI降低的原因：前负荷下降：出血 心肌收缩力下降：心功能不全（EF%）后负荷增加：SVR增加2020-12-08肺动脉漂浮导管PA
32、C（新课件）64PAC参数整合：氧代谢2020-12-08肺动脉漂浮导管PAC（新课件）65Oxygen Delivery:What are the components?Oxygen DeliveryDO2Cardiac OutputHeart RateStroke VolumeCaO2PaO2SaO2HbPreloadAfterloadContractilityCVPPCWPPVRSVREF%2020-12-08肺动脉漂浮导管PAC（新课件）66PAC目标指导性治疗 CI 4.5L/min/m2 DO2600mL/min/m2 VO2170mL/min/m2Shoemaker WC et
33、al.Chest.1988 Dec;94(6):1176-86.2020-12-08肺动脉漂浮导管PAC（新课件）67PAC目标指导性治疗Crit Care Med.2002 Aug;30(8):1686-92v CI 4.5L/min/m2v DO2600mL/min/m2v VO2170mL/min/m2v PAWP18mmHg2020-12-08肺动脉漂浮导管PAC（新课件）68基于基于PAC参数的常见危重病的诊断参数的常见危重病的诊断2020-12-08肺动脉漂浮导管PAC（新课件）69基于PAC参数的急性右心衰诊断前负荷前负荷CVPPAWP正常后负荷后负荷MPAP正常或MAP正常或心
34、脏心脏HRSI氧代谢氧代谢PaO2/FiO2DO2VO22020-12-08肺动脉漂浮导管PAC（新课件）70基于PAC参数的急性左心衰诊断前负荷前负荷CVPPAWP后负荷后负荷PVR/SVR MAP正常或心脏心脏HRSI氧代谢氧代谢PaO2/FiO2DO2VO22020-12-08肺动脉漂浮导管PAC（新课件）71基于PAC参数的感染性休克诊断前负荷前负荷CVPPAWP后负荷后负荷SVR MAP正常或心脏心脏HRSI氧代谢氧代谢PaO2/FiO2DO2VO22020-12-08肺动脉漂浮导管PAC（新课件）72基于PAC参数的失血性休克诊断前负荷前负荷CVPPAWP后负荷后负荷SVR MAP
35、正常或心脏心脏HRSI氧代谢氧代谢PaO2/FiO2DO2正常或VO22020-12-08肺动脉漂浮导管PAC（新课件）73基于PAC参数的急性肺栓塞诊断前负荷前负荷CVPPAWP后负荷后负荷MPAPMAP正常或心脏心脏HRSI氧代谢氧代谢PaO2/FiO2DO2VO22020-12-08肺动脉漂浮导管PAC（新课件）74PAC病例病例2020-12-08肺动脉漂浮导管PAC（新课件）75Case 1 Fluid challenge2020-12-08肺动脉漂浮导管PAC（新课件）76Case 2 Fluid challenge2020-12-08肺动脉漂浮导管PAC（新课件）77Case 2
36、 Diuretic 2020-12-08肺动脉漂浮导管PAC（新课件）78Case 2 Diuretic2020-12-08肺动脉漂浮导管PAC（新课件）79Case3 Vasodilator Therapy 71/M Anterior wall myocardial infarction PE:BP 132/82 HR 116 R 28.+2 edema of the lower extremities Lab:Na 132 Scr 88 ECG:anterior lead S-T elevations CRX:cardiomegaly with pulmonary edema The pa
37、tient was admitted to the ICU and PAC was placed for optimization of cardiac status Nitroprusside was titrated2020-12-08肺动脉漂浮导管PAC（新课件）80Case3 Vasodilator Therapy2020-12-08肺动脉漂浮导管PAC（新课件）81Case 4 Cardiac tonic2020-12-08肺动脉漂浮导管PAC（新课件）82Case 4 Cardiac tonic2020-12-08肺动脉漂浮导管PAC（新课件）83Case 5 Septic Sho
38、ck 52/F ESWL;urinary tract infections BP 100/45 HR 120 RR 40 T 39 WBC 13100,Na 138,K 5.1,Glu 16,scr 180 CRX:normal ；EKG:sinus tachycardia.Urine Cultures；started on mezlocillin and gentamicin.On day2，SBP dropped to 70 mmHg；ABG（Fi02 60%）:pH 7.38,PaO2 42,PaCO2 49 Sa02 75%.CRX showed diffuse bilateral i
39、nfiltrates.Transferred to the ICU：volume resuscitated,intubated and started on intravenous inotropes and vasopressors.PAC was inserted.The patient remained oliguric,uremic and therefore hemodialysis was started.MV was maintained with high FiO2 and PEEP2020-12-08肺动脉漂浮导管PAC（新课件）84Case 5 Septic Shock2020-12-08肺动脉漂浮导管PAC（新课件）852020-12-08肺动脉漂浮导管PAC（新课件）86谢谢感谢您的聆听您的关注使我们更努力
