1、内化内化第一信号第一信号第二信号第二信号somatic hypermutationsomatic hypermutation&Affinity Maturation&Affinity MaturationFive BCR:all specific for different affinitiesBBBBBOnly this cell,that has a high affinity,is rescued from apoptosis i.e.clonally selectedThe cells with lower affinity receptors die of apoptosis Ig
2、Ig类别转换类别转换ThTh B7 B7MHC-II TCR CD4 ICAM LFA-1 ICAM LFA-1APCAPCThThB BCD40L CD40CD40L CD40分泌细胞因子分泌细胞因子ThBBBTh Th 细胞活细胞活化、增殖化、增殖B B 细胞扩细胞扩增增浆细胞浆细胞BCRBCR抗原抗原TD 抗 原 诱 导 体 液 免 疫 应 答 的 过 程BmBm CD28 CD28THANK YOUSUCCESSBCRBCR交联交联信号转导信号转导TI-2TI-2诱导的诱导的B B细胞应答细胞应答B B细胞细胞TI-1 Ag TI-1 Ag 和和 TI-2 AgTI-2 Ag吞噬细胞吞
3、噬吞噬细胞吞噬AgAg结合结合IgG/IgM-AgIgG/IgM-Ag激活补体激活补体C3bC3b巨噬细胞巨噬细胞C3bC3b受体受体结合结合40写在最后写在最后成功的基础在于好的学习习惯成功的基础在于好的学习习惯The foundation of success lies in good habits谢谢聆听 学习就是为了达到一定目的而努力去干,是为一个目标去战胜各种困难的过程,这个过程会充满压力、痛苦和挫折Learning Is To Achieve A Certain Goal And Work Hard,Is A Process To Overcome Various Difficulties For A Goal
