1、抗结核药物知识讲座 肺结核肺结核 含义含义：结核杆菌引起的慢性肺部传染性疾病。临床表现临床表现：慢性病，低热、消瘦、咳嗽、咯血，病程长。抗结核药物知识讲座2抗结核药物知识讲座3抗结核药物知识讲座4抗结核药物知识讲座5抗结核药物知识讲座6抗结核药物知识讲座7抗结核药物知识讲座8NNHNH2O 化学名：化学名：4-4-吡啶甲酰肼吡啶甲酰肼抗结核药物知识讲座9HNOOHNNHNH2SCHCH3 3抗结核药物知识讲座10HNOOHNNHNH2SNNNHNH2S乙酰胺基苯甲醛缩乙酰胺基苯甲醛缩氨硫脲氨硫脲 异烟醛缩氨硫脲异烟醛缩氨硫脲CHCH3 3抗结核药物知识讲座11NNHNH2O 异烟肼异烟肼抗结核
2、药物知识讲座12 异烟酸异烟酸 烟酸烟酸抗结核药物知识讲座13抗结核药物知识讲座14抗结核药物知识讲座15NNHNH2O抗结核药物知识讲座16NNHNH2O抗结核药物知识讲座17抗结核药物知识讲座18NNH2ONOMONHNONHNHNHNO异烟酸盐异烟酸盐异烟酰胺异烟酰胺二异烟酰双肼二异烟酰双肼抗结核药物知识讲座19NONHNH2NOOHAgNO3Ag抗结核药物知识讲座20抗结核药物知识讲座21乙酰肼乙酰肼抗结核药物知识讲座22抗结核药物知识讲座23NONHNH2NOOHNH2NH2NCH3O2,V2O5抗结核药物知识讲座24NNHNH2O异烟肼为基本药效基团，可做成腙作为前药异烟肼为基本药
3、效基团，可做成腙作为前药抗结核药物知识讲座25NCONHNH=CHOHOCH3异烟腙异烟腙NNNOHOOOHOHOH葡烟腙葡烟腙抗结核药物知识讲座26NNNOCaONNOOOONCH3CH3HH抗结核药物知识讲座27抗结核药物知识讲座28抗结核药物知识讲座29CH3CHNHNHCHOHOHCH312341234*(（2R,2R)-(+)2,2-(1,2-2R,2R)-(+)2,2-(1,2-乙二亚氨基）双丁醇乙二亚氨基）双丁醇二盐酸盐二盐酸盐抗结核药物知识讲座30抗结核药物知识讲座31抗结核药物知识讲座32抗结核药物知识讲座33OHOOHH2N抗结核药物知识讲座34OHOOHOOHNH2O H
4、OO H苯甲酸苯甲酸水杨酸水杨酸对氨基水杨酸对氨基水杨酸抗结核药物知识讲座35抗结核药物知识讲座36抗结核药物知识讲座37COOHOHH2NNCONHNH2抗结核药物知识讲座38吡嗪酰胺吡嗪酰胺 烟酸烟酸 吡嗪酰胺吡嗪酰胺抗结核药物知识讲座39抗结核药物知识讲座40NSNH2CH3NSNH2CH3乙硫异烟胺乙硫异烟胺丙硫异烟胺丙硫异烟胺抗结核药物知识讲座41抗结核药物知识讲座42抗结核药物知识讲座438 8（4 4甲基甲基1 1哌嗪基）亚氨基哌嗪基）亚氨基 甲基甲基 利利福霉素福霉素 O HO HN HOC H3OOC H3OCH3OCH3CH3H3COOCC H3C H3C H3O HO H
5、O HNNNC H312345678910111213141920212425262714抗结核药物知识讲座44O HO HNHOC H3OOC H3OCH3OCH3CH3H3COOCC H3C H3C H3O HO HRR123456789101112131419202124252627抗结核药物知识讲座45OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHOCH2COOHH123456789101112131419202124252627抗菌作用弱抗菌作用弱抗结核药物知识讲座46O HO HN HOC H3OOC H3OCH3OCH3CH3H3COO
6、CC H3C H3C H3O HO HO HH123456789101112131419202124252627口服吸收差，而且对革兰氏阴性菌的作用弱口服吸收差，而且对革兰氏阴性菌的作用弱抗结核药物知识讲座47OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHOHNNNCH3123456789101112131419202124252627抗结核药物知识讲座48抗结核药物知识讲座49抗结核药物知识讲座50OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHOHH1234567891011121314192021242
7、52627抗结核药物知识讲座52抗结核药物知识讲座53抗结核药物知识讲座54OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHRR123456789101112131419202124252627抗结核药物知识讲座55OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHRR123456789101112131419202124252627抗结核药物知识讲座56OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHRR123456789101112131419202124252627
8、抗结核药物知识讲座57OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHRR123456789101112131419202124252627抗结核药物知识讲座58环丝氨酸环丝氨酸抗结核药物知识讲座59抗结核药物知识讲座60抗结核药物知识讲座61抗结核药物知识讲座62OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHRR123456789101112131419202124252627抗结核药物知识讲座63OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHRR123456789101112131419202124252627抗结核药物知识讲座64OHOHNHOCH3OOCH3OCH3OCH3CH3H3COOCCH3CH3CH3OHOHRR123456789101112131419202124252627抗结核药物知识讲座65
