1、【医学课件】肾病总论（英语）张玖强(1)kidney L T11L2 R T12L310cm in length5cm in width4cm in thickness134 148g in weight(1)kidney(2)Renal Cortex4renal cortex 8090%of glomerulus Glomerular capsule4 renal medulla renal tubule(3)Glomerulus4Glomerular Filtration Membrane endothelial cells basement epithelial cells(4)Rena
2、l tubule4proximal convolute reabsorption4distal convolute regulating of acid-base balanceRenal tubular diseases(renal,tubular,acidosis)Type(dRTA)Type(pRTA)+(5)Renal InterstitiumInterstitial cellsFibrocyteExtracelluar matrixPathogenic microorganismimmunoreactionAcute interstitial nephritisChronic int
3、erstitial nephritisInterstitium(6)Renal Pelvis,Ureter Pathogenic microorganism(upper urinary tract)(7)Urinary Bladder,UrethraUrinary bladderUrethra(Lower urinary tract)Pathogenicmicroorganism 4(proteinuria3.5g/day)4Proteinuria+nephrotic syndrome4proteinuria150mg/24hrglomerular tubular overflow secre
4、tory or1.5g/24hr 1.5g/24hr immunoglobulin histic2-microglobulinInfectiontoxicity Bence JonesproteinmyelomaSelective(albumin)NonSelective(mixture)Dysmorphic Rbc Hemogeneous RbcCalculus,tumor,TB,infectionGlomerular diseaserenal parenchymaRenal vesselArleriae renalis stenosisvolume dependentrenin depen
5、dentEdemaGlomerular Filtrate Rate(GFR)Plasma colloid osmotic pressure AnasarcaLocal edemaLower extremity edemaCommon Clinical Laboratory Assessment of Renal DiseaseCell protein cast glomerular tubular IVP CT renal biopsy MRI Cr Ccr GFR PSP MosthsRenal diseaseurinalysisRenal functionSpecial examinationRemoval causesCorticosteroidImmunosuppressiveSymptomatic and supportingAnti-inflammatoryChinese herbsRenal failure4dialysis HD PD
