1、LOGODepartment of Endocrinologythe First Affiliated Hospital,Chongqing Medical UniversityCheng Qingfeng程庆丰程庆丰contentWhat Causes Gout?2Signs and Symptoms 3 How Is Gout Diagnosed 4Remedies 5What Is Gout?1DefinitionvGout：Hyperuricemia Arthritis uratoma joint deformity、dysfunction disrupt kidney and kid
2、ney stoneshyperuricemia：asymptomaticpurine uric acid Gout：acute arthritis Tophi Complication of Kidney contentWhat Causes Gout?2Signs and Symptoms 3 How Is Gout Diagnosed 4Remedies 5What Is Gout?1pathogenesisTextGoutTextprimary secondary TextMetabolism of UAvsource：exogenous：endogenous：vexcretion：ki
3、dney：mainly intestinal tract:Pathogenesis and typingvGenerate increased：vExcretion reduction：vmixedcontentWhat Causes Gout?2Signs and Symptoms 3 How Is Gout Diagnosed 4Remedies 5What Is Gout?1epidemiologyv agev genderv Family History v metabolic syndromestageChronic goutInterval goutAcute gout Asymp
4、tomatic hyperuricemia vhigh levels of uric acidvno other symptoms Asymptomatic hyperuricemia big toe fingers TophiTophiKidney damageKidney damagevGout nephropathyvkidney stonescontentWhat Causes Gout?2Signs and Symptoms 3 How Is Gout Diagnosed 4Remedies 5What Is Gout?1DiagnosisDiagnosisvphysical exa
5、m vPerforming blood tests vjoint fluid test vauxiliary examinationdifferential diagnosis vrheumatic arthritis：vrheumatoid arthritis：vtraumatic arthritis：vsuppurative arthritis：vpseudogout contentWhat Causes Gout?2Signs and Symptoms 3 How Is Gout Diagnosed 4Remedies 5What Is Gout?1treatment1234Acute：
6、limit the pain Interval&chronic：excrete UA360Complication metabolic syndromeAcuteAcutevRestvColchicinesvNon-steroidal anti-inflammatory drugs(NSAIDs)vCorticosteroids Interval&chronicvInhibit uric acid synthesis allopurinol ;FebuxostatvPromote the excretion of uric acid Phenyl bromide Malone;probenecid Prognosis If no renal lesions,the prognosis of primary gout is good.v思考题：思考题：v原发性痛风急性关节炎的鉴别诊断？原发性痛风急性关节炎的鉴别诊断？v原发性痛风的治疗原则？原发性痛风的治疗原则？LOGO
