1、PPHN4PPHN5PPHN6Synthesis and release of endothelium-derived NO and its effect on its target,vascular smooth muscle.Increases in cGMP levels in the smooth muscle lead to vasodilation.Phosphodiesterase limits the duration of the vasodilation by breaking down cGMP.PPHN7PPHN8Synthesis and release of PGI
2、2 from arachidonic acid and endoperoxides by cyclooxygenase and PGI2 synthase.Prostacyclin increases cAMP levels in vascular smooth muscle leading to vasodilation,which is regulated by a specific phosphodiesterasePPHN9PPHN10PPHN11PPHN12PPHN13PPHN14PPHN15PPHN16PPHN19PPHN21PPHN22PPHN23PPHN24As NO diff
3、uses from the alveolus to the adjacent pulmonary artery,relaxation of vascular smooth muscle occurs.NO that diffuses into the lumen of the artery is bound to hemoglobin and inactivated in the red cell to nitrite and nitrate(NO2+NO3).PPHN2527CtliNOECMO ECMO Died Died Ctl iNO Ctl iNOTotals506579 43%29
4、%10%9%p 0.001 p=0.477PPHN28The total number of infants cannulated for ECMO decreased over time.All of this decrease was in infants with respiratory failure due to MAS,sepsis,pneumonia,RDS,and idiopathic PPHN.The number of infants cannulated for CDH was stable over the three time periods.PPHN29PPHN30
5、PPHN31PPHN32PPHN33As NO diffuses from the alveolus to the adjacent pulmonary artery,relaxation of vascular smooth muscle occurs.NO that diffuses into the lumen of the artery is bound to hemoglobin and inactivated in the red cell to nitrite and nitrate(NO2+NO3).PDE5 inhibitors action increases cGMP.PPHN34PPHN35PPHN36PPHN37PPHN38PPHN39PPHN40PPHN42PPHN43PPHN44
