1、 6-P-glucoseFused PET/CT scatter correction attenuation correctionSpiral CT: 1-2 min4080 mAs; 140 kVpWB PET: 28 min60 min uptakePETCTPET18F-FDG58 mCi I.V.C TFUSIONRESTSUV =Diagnosis, Staging, and Restaging (unless otherwise indicated)follicular: I -131 neg, Tg 10 ng/dLnot breast masses or regional n
2、odesCT/MRI neg for extra-pelvic metsnot regional nodesonly non-small cellwhen enrolled in NOPRSPN1%Melanoma4%Esophageal Cancer8%Colorectal Cancer5%NSCLC15%Lymphoma47%Thyroid Cancer 1%Breast Cancer5%Head & Neck Cancer4%PET Tumor Imaging Misc10%CED, coverage with evidence development; NC, non-covered;
3、( (良恶性病变鉴别良恶性病变鉴别) )( (临床分期和分临床分期和分级级) )( (制定治疗方案制定治疗方案) )( (辅助制定放疗计划辅助制定放疗计划) )( (放疗放疗/ /术术后残留后残留/ /复发与坏死复发与坏死/ /瘢痕组织鉴别）瘢痕组织鉴别）（疗效监测评价，预后判断）疗效监测评价，预后判断）（寻找原发肿瘤病灶）（寻找原发肿瘤病灶） SPN Meta-analysis Lung cancer with brain metastasisLung cancer with liver，adrenal gland and osseous metastasesLung cancer with
4、 mediastinum lymph nodes， liver metastasessurgeryNo surgerySome surgeryMonitoring Response63 year old man stage 3A lung cancer, has received 4 cycles of chemotherapy Breast cancerBreast cancer with lymph nodes and osseous metastases liver metastasis Rectal carcinomaPancreatic cancer with liver metas
5、tasesLiver cancer18F-FDG PET/CT已经建议作为恶性淋巴瘤的初始分期、再分期及疗效随访的标准影像技术。Lymphoma（right tonsil） with cervical lymph node metastasis LaryngocarcinomaIII-IV A BMelanoma with inguinal lymph node metastasis a 58-year-old male with brain metastasis (be surgically removed). A: The whole body PET image showed incre
6、ased uptake (red arrow). B: Focus tracer uptake was shown in the right apex (red arrow). Histology confirmed to be large-cell anaplastic carcinoma.PET的成本效益分析的成本效益分析临床分期与治疗抉择临床分期与治疗抉择Problems and Pitfalls False positive findingsNormal physiologyGranulomas and other infectionsAdenomasTumor histologyLe
7、sions smaller than 8 mmDiabetes/Non-fasting patients False negative findings56 year man with HCV, end stage liver disease, and presumed hepatomaStandard CTPET/CTPhysiologic Uptake: Brown Fat68 year old man with solitary lung nodule. Biopsy: aspergillosis (曲霉菌）Tuberculosis of lymph nodesClinical Impa
8、ct of PET/CT More accurate diagnosis Avoidance of unnecessary tests, and (potentially) harmful procedures Better treatment or management36.5% change in decision to treat or not treatStage IStage IIStage IIIpapillary adenocarcinoma甲状腺乳头状腺癌Hyperparathyroidism99mTc-MIBI鼠肿瘤模型99mTc-Annexin V凋亡显像（A为对照；B为环磷酰胺处理后24h行凋亡显像，箭头处放射性浓聚灶示肿瘤凋亡） 艾氏腹水癌昆明小鼠模型99mTc-HL91乏氧显像89Zr 标记的抗体-热点CarcinoidMetastatic medullary cancer of thyroid
