1、药物EPS催乳素体重氯氮平00+奥氮平+0+利培酮+喹硫平00+齐拉西酮+0+阿立哌唑+0+氟哌啶醇+ReferenceDavis JM.N Engl J Med 2006;254(5):518-20氨磺必利氯氮平阿立哌唑奥氮平利培酮喹硫平佐替平舍吲哚齐拉西酮 与氟哌啶醇比较，氯氮平、奥氮平、喹硫平、利培酮均能引起患者体重的增加；阿立哌唑、齐拉西酮与氟哌啶醇比较没有显著性差异ReferenceStefan Leucht，Second-generation versus fi rst-generation antipsychoticdrugs for schizophrenia:a meta-a
2、nalysis；Lancet 2009;373:3141Reference Bruce J.Long-Term Olanzapine Treatment:Weight Change and Weight-Related Health Factors in Schizophrenia.J Clin Psychiatry 2001;62:92100Reference1赵靖平,二甲双胍联合行为干预治疗抗精神病药所致体质量增加及糖代谢紊乱的研究，中华精神科杂志，2007，4：193-1962杨艳，非典型抗精神病药物所致的体重增加及应对策略，重庆医科大学学报，2007，8：888-892Referenc
3、ePendlebury J,et al:Long-term maintenance of weight loss in patients with severe mental illness through a behavioural treatment programme in the UK。Acta Psychiatr Scand.2007 Apr;115(4):286-94 行为干预治疗包括：患者间交流、健康饮食计划、患者教育、增加运动等措施平均体重增加（kg）6.86.83.73.75.05.06.96.92.42.41.51.52.32.36.86.80 01 12 23 34 45
4、 56 67 7奥氮平氟哌啶醇利培酮氯氮平无干预组有干预组Reference1赵靖平,二甲双胍联合行为干预治疗抗精神病药所致体质量增加及糖代谢紊乱的研究，中华精神科杂志，2007，4：193-196Reference1赵靖平,二甲双胍联合行为干预治疗抗精神病药所致体质量增加及糖代谢紊乱的研究，中华精神科杂志，2007，4：193-196128例首发精神分裂症观察12周，每组32例Reference1赵靖平,二甲双胍联合行为干预治疗抗精神病药所致体质量增加及糖代谢紊乱的研究，中华精神科杂志，2007,4：193-196行为干预行为干预+二甲双胍二甲双胍二甲双胍二甲双胍行为干预行为干预安慰剂安慰剂
5、-16-14-12-10-8-6-4-2024体重体重(Kg)BMI腰围腰围(cm）空腹血糖空腹血糖(mg/dl)）胰岛素胰岛素(uIU/ml）IRIReference1赵靖平,二甲双胍联合行为干预治疗抗精神病药所致体质量增加及糖代谢紊乱的研究，中华精神科杂志，2007，4：193-196Reference1 David J.A Randomized,Double-Blind,Placebo-Controlled Trial ofMetformin Treatment of Weight Gain Associated With Initiationof Atypical Antipsycho
6、tic Therapy in Children and Adolescents.Am J Psychiatry 2006;163:20722079Reference David J.A Randomized,Double-Blind,Placebo-Controlled Trial ofMetformin Treatment of Weight Gain Associated With Initiationof Atypical Antipsychotic Therapy in Children and Adolescents.Am J Psychiatry 2006;163:20722079
7、Reference David J.A Randomized,Double-Blind,Placebo-Controlled Trial ofMetformin Treatment of Weight Gain Associated With Initiationof Atypical Antipsychotic Therapy in Children and Adolescents.Am J Psychiatry 2006;163:20722079二甲双胍与安慰剂比较体重指数腰围Reference David J.A Randomized,Double-Blind,Placebo-Contr
8、olled Trial ofMetformin Treatment of Weight Gain Associated With Initiationof Atypical Antipsychotic Therapy in Children and Adolescents.Am J Psychiatry 2006;163:20722079P=0.002Reference David J.A Randomized,Double-Blind,Placebo-Controlled Trial ofMetformin Treatment of Weight Gain Associated With I
9、nitiationof Atypical Antipsychotic Therapy in Children and Adolescents.Am J Psychiatry 2006;163:20722079安慰剂组试验组Reference David J.A Randomized,Double-Blind,Placebo-Controlled Trial ofMetformin Treatment of Weight Gain Associated With Initiationof Atypical Antipsychotic Therapy in Children and Adolescents.Am J Psychiatry 2006;163:20722079 服务社会服务社会 营造健康营造健康
