1、CH3H3CHOHOHHOOOOOH3CHOOH3COHOCH3HOHOCH3H3CHOHOHHOOOOH3CHOOH3COHOCH3OAcOOHHOHOHOHOOCH3HOCHOHOHHOOOH3CH3COOOHHOHOOHOCH3HOCHOHOHHOOH3CHOHOOOHCH3H3CHOHOHHOOOOOH3CHOOH3COHOCH3HOHOOHNH2CHHOHH3CON89OCH2CF3OCH2CF3NHHNOCH3COOH.*ONHOOHCH3*作用机理：作用机理：OCH3OOHCH3OHOOPt/C H2OHOOHOClOOOH2NCH3AlCl3ONHOOHCH3*OCH3OIIO
2、NCH3CH3HClO2NOONO2ONO2OOO2NOONO2HH乳糜微粒 脂蛋白 脂肪酶肝脏LDLR脂肪和肌肉组织FFA胆汁(胆固醇或盐)外原性途径食物脂质肠VLDLIDLLDLLDLRHDLFCFFA 脂蛋白 脂肪酶LCAT肝外组织内原性途径遗留物外源性和内原性脂质转运和代谢途径外源性和内原性脂质转运和代谢途径OOH3CHCH3H3COHOHCH3OFNCH3CH3OO-Na+HOOHOOHH3CCH3OClClClONHH3CCH3ONHNOO 环丙贝特环丙贝特 普拉贝脲普拉贝脲芳香环-O-空间连接链H3CH3COHOClOOCH3H3CCH3O（2）改良合成方法）改良合成方法ClOHCH3COCH3,CHCl3NaOHClOONa+H3CCH3OClOOH3CCH3OCH3CH3CH2OHOHCH3COCH3,CHCl3NaOHOONa+H3CCH3OCH3CH2OHCl2H2SO4CH3CH3OOHH3CCH3OCH3CH3OBr+H3COCH3OCH3OOCH3CH2ONaCH3CH3OCO2CH2CH3H3CCO2CH2CH3NaOHHClCH3CH3OOHH3COCH3ICH3CH2ONaCH3CH3OONaH3CCH3OCH3CH3OOHH3CCH3OHCl
