1、1第三篇 医学相关病毒2教学大纲3问题4呼吸道病毒种类5流感病毒（Influenza Virus）6生物学性状7n80-120 nmn8 Structural proteins:uGlycoproteinsvHA (H1-H15)vNA (N1-N9)uM1, M2u8 nucleocapsid segmentsvRNA, NP, PB1, PB2, PAnHA-attachment to receptors,initiationnNA-degradation of receptors, release8主要抗原结构9血凝素（Hemagglutinin, HA）10神经氨酸酶（Neuramin
2、idase, NA）11抗原变异机制12Influenza pandemics associated with antigenic shift13致病性141516Influenza natural course17181920微生物学诊断21Specimens: throat swabs, NPS, nasal aspirates, sputumCulture: conventional, rapidDirect detection (EIA, IF, PCR)Serologic response: 4-fold or greater rise in IgG titers22预防2324NA
3、 Inhibitor25副粘病毒（Paramyxoviruses） 26副粘病毒共同性状 27麻疹病毒（Measles Virus）28293031323334副流感病毒3536呼吸道合胞病毒Respiratory Syncytial Virus，RSV3738腮腺炎病毒（Mumps virus）3940风疹病毒（Ruella virus）41致病性42预防及免疫43冠状病毒 Coronavirus，CoV44重症急性呼吸综合症冠状病毒SARS Coronavirus, SARS CoV45SARS症状46474849生物学性状50SARS Genome51SARS传播和流行52中国的SARS流行5354诊断55预防56575859Summary: Respiratory Infected Viruses60Influenza Viruses61Variation62Other Respiratory Infected Viruses63小结64
