Hepatic encephalopathy(HE)is a complex,potentially reversible disturbance in central nervous system that occurs as a consequence of severe liver diseases.It is characterized by neuropsychical mani-festation ranging from a slightly altered mental status to coma.(差 精神错乱扑翼样震颤 flapping tremor(asterixis)昏睡(lethargy)asleep but can be roused (NADH NAD ATP ADP星形胶质细胞 NADHNAD:-酮戊二酸脱氢酶 血-酮戊二酸消耗NADH消耗ATP消耗ClClBRGABARGABACell22 GABA/BZBZ激动性配体反激动性配体拮抗性配体 Cl-Cl-前膜去极化for example;(假性神经介质正常神经递质)liver 脑脑干干网网状状结结构构与与觉觉醒醒