1、前列腺癌精准医学精精准医学（准医学（Precision Medicine）Precision medicine is a medical model that proposes the customization of healthcarewith medical decisions,practices,and/or products being tailored to the individual patient.In this model,diagnostic testing is often employed for selecting appropriate and optimal t
2、herapies based on the content of a patientss genetic content or other molecular or cellular analysis.DNA Damage Repair gene（DDR）Cancer Treat Rev.2016 Mar;44:1-9.胚系胚系BRCA2突变与前列腺癌恶性突变与前列腺癌恶性程度相关程度相关Clin Cancer Res.2010 Apr 1;16(7):2115-21.胚系胚系BRCA2突变与前列腺癌复发突变与前列腺癌复发、进展和死亡相关、进展和死亡相关体细胞体细胞BRCA2突变与前列腺癌进展
3、相关突变与前列腺癌进展相关8%Prostate.2016 May 26.Epub ahead of print N=150，mCRPC，肿瘤组织 多中心，692例mPC，检测胚系DDR基因突变mPC中中DDR基因缺陷的发生率为基因缺陷的发生率为11.8%，而局灶性肿瘤中只有而局灶性肿瘤中只有4.6%随着疾病进展，胚系DDR基因突变风险逐渐增加精准医学Whole-exome sequencing;germline whole-exome sequencingl 16例/49（33%）的患者存在DDR基因缺陷，其中胚系遗传缺陷的有6例（12.2%）l 14/16(88%)的患者对Olaparib治疗有反应多靶点联合液体活检液体活检液体活检液体活检前列腺癌分子分型前列腺癌分子分型Ann Oncol.2015 Jun;26(6):1041-2.未来研究模式Clin Cancer Res.2014;20(19 Suppl):S1-S112.
