1、Department of Microbiology,Guangzhou Medical CollegeDepartment of Microbiology,Harbin Medical UniversityDepartment of Microbiology,Guangzhou Medical College案例9-1Department of Microbiology,Guangzhou Medical College分析Department of Microbiology,Guangzhou Medical College第9章 呼吸道传播的病原微生物Department of Micr
2、obiology,Guangzhou Medical College流行病学Department of Microbiology,Guangzhou Medical College分枝杆菌属（Mycobacterium）Department of Microbiology,Guangzhou Medical College结核分枝杆菌复合群结核分枝杆菌复合群结核分枝杆菌结核分枝杆菌牛分枝杆菌、牛分枝杆菌、非洲分枝杆菌非洲分枝杆菌田鼠分枝杆菌田鼠分枝杆菌非典型分枝杆菌非典型分枝杆菌麻风分枝杆菌麻风分枝杆菌光产色分枝杆菌光产色分枝杆菌暗产色分枝杆菌暗产色分枝杆菌不产色分枝杆菌不产色分枝杆菌迅速生长
3、分枝杆菌迅速生长分枝杆菌分枝杆菌属分枝杆菌属Department of Microbiology,Guangzhou Medical College一、生物学性状一、生物学性状1）、形态上：）、形态上：菌体细长稍菌体细长稍弯曲。弯曲。呈分枝状生长趋势，呈分枝状生长趋势，经齐尼经齐尼(Ziehl-Neelsen)抗抗酸染色法染色后，菌体呈红酸染色法染色后，菌体呈红色（色（抗酸染色阳性抗酸染色阳性），其他），其他非抗酸菌及细胞杂质等均被非抗酸菌及细胞杂质等均被染成蓝色。染成蓝色。1、形态与染色Department of Microbiology,Guangzhou Medical College2
4、、培养特性、培养特性培养基含鸡蛋、马铃薯粉、甘油、孔雀绿等培养基含鸡蛋、马铃薯粉、甘油、孔雀绿等Department of Microbiology,Guangzhou Medical CollegeDepartment of Microbiology,Guangzhou Medical CollegeDepartment of Microbiology,Guangzhou Medical CollegeDepartment of Microbiology,Guangzhou Medical CollegeDepartment of Microbiology,Guangzhou Medical
5、 CollegeDepartment of Microbiology,Guangzhou Medical College二、致病性和免疫性 1、致病物质Department of Microbiology,Guangzhou Medical College2、所致疾病 Department of Microbiology,Guangzhou Medical College肺部感染原发感染Department of Microbiology,Guangzhou Medical College 原发感染Department of Microbiology,Guangzhou Medical Col
6、lege肺部感染继发感染Department of Microbiology,Guangzhou Medical College肺外感染 Department of Microbiology,Guangzhou Medical College免疫机制Department of Microbiology,Guangzhou Medical College免疫与超敏反应 Department of Microbiology,Guangzhou Medical College局部红肿、浅溃疡不扩散以前感染过或免疫豚鼠正常豚鼠局部红肿、溃疡坏死，经久不愈全身扩散有毒TB菌Department of M
7、icrobiology,Guangzhou Medical College结核菌素试验Department of Microbiology,Guangzhou Medical College结核菌素试验Department of Microbiology,Guangzhou Medical College结核菌素试验结果分析硬结、红肿直径0.5-1.5cm之间出现超敏反应不表示正患结核病硬结直径超过1.5cm以上表明可能有活动性结核，应进一步检查注射部位有针眼大的红点或稍有红肿，硬结直径小于0.5cm无结核感染，但应考虑：无结核感染，但应考虑：原发感染的早期原发感染的早期正患严重结核病正患严重
8、结核病正患其他传染病（麻疹）正患其他传染病（麻疹）Department of Microbiology,Guangzhou Medical College结核菌素试验应用Department of Microbiology,Guangzhou Medical College三、微生物学检查Department of Microbiology,Guangzhou Medical College特异性防治Department of Microbiology,Guangzhou Medical College麻风分枝杆菌Department of Microbiology,Guangzhou Med
9、ical College麻风分枝杆菌（M.leprae）Department of Microbiology,Guangzhou Medical College形态与染色Department of Microbiology,Guangzhou Medical College培养特性Department of Microbiology,Guangzhou Medical College致病性Department of Microbiology,Guangzhou Medical College麻风两型两类相互间的关系图麻风两型两类相互间的关系图Department of Microbiology
10、,Guangzhou Medical College微生物学诊断Department of Microbiology,Guangzhou Medical College防治原则Department of Microbiology,Guangzhou Medical College非结核分枝杆菌Department of Microbiology,Guangzhou Medical College非结核分枝杆菌Department of Microbiology,Guangzhou Medical College分类Department of Microbiology,Guangzhou Medical College偶发分枝杆菌光产色菌提问与解答环节Questions And Answers谢谢聆听 学习就是为了达到一定目的而努力去干,是为一个目标去战胜各种困难的过程,这个过程会充满压力、痛苦和挫折Learning Is To Achieve A Certain Goal And Work Hard,Is A Process To Overcome Various Difficulties For A Goal
