1、泌尿生殖系统泌尿生殖系统疾病疾病Genitourinary system第三节第三节 肾小管和肾间质疾病肾小管和肾间质疾病 第三节第三节 肾小管和肾间质疾病肾小管和肾间质疾病 生殖系统及乳腺疾病生殖系统及乳腺疾病The female genital system and breast 子宫颈疾病子宫颈疾病 Disease of cervixRobin Basic Pathology 9thSexual activityHPV infection(106/yr)Condyloma(102-103/yr)Low-risk HPV(6,11)PersistentinfectionHigher-gra
2、de CIN(300,000/yr)Invasive cancer(10500/yr)Metastasis(5000/yr)CIN(106/yr)High-risk HPV(16,18,others)Robin Basic Pathology 9th妊娠滋养细胞疾病妊娠滋养细胞疾病Gestational trophoblastic disease 特征特征 完全性葡萄胎完全性葡萄胎 部分性葡萄胎部分性葡萄胎 核型核型 46,XX or 46,XY 69,XXY绒毛水肿绒毛水肿 all villi some villi滋养层细胞滋养层细胞 diffused focal,slight 增生增生异型
3、性异型性 often present absent血清中血清中 hCG elevated less elevated组织中组织中hCG +预后预后 2%canceration rare cancerationBreast diseases Representation of findings in a series of women seeking evaluation of apparent breast“lumps”.World Cancer Report 2014World Cancer Report 2014Cancer Statistics 2015 In 2010,more tha
4、n 200,000 invasive breast cancers were diagnosed in women in the United States,and around 40,000 women died of this disease,making this scourge second only to lung cancer as a cause of cancer-related death in women.The lifetime risk of developing breast cancer is 1 in 8 for women in the United States.Robin Basic Pathology 9th2014中国肿瘤登记年报Invasive ductal carcinomaInvasive lobular carcinomaMedullary carcinomaTubular carcinomaMucious carcinomaOther typesDuctal CarcinomaIn SituLobular CarcinomaIn Situ15-30%70-85%乳腺硬癌乳腺硬癌
