1、Arachidonic acidCollagenvWFThrombinEpinephrineADPTxA2GPIIb/IIIaactivationAspirinClopedigrelTiclopidineHeparinHirudinLMWHPlatelet aggregationThrombus formationGPIIb/IIIa receptor blocker缺血卒中和体循环栓塞相对危险(来自5个一级预防试验中治疗对照组)华法调整剂量与安慰剂比较AFASAKI(1)SPAF(3)BAATAF(9)CAFA(14)SPINAF(13)EAFT(16)All Trials(n=6)100%
2、-50%50%-100%0Warfarin BetterWarfarin WorseRelative Risk Reduction(95%CI)阿斯匹林与安慰剂比较100%-50%50%-100%0Warfarin BetterWarfarin WorseAFASAKI(1)SPAF I(3)EAFT(9)ESPS II(14)LASAF(13)UK-TIA(16)All Trials(n=6)Relative Risk Reduction(95%CI)华法令与阿斯匹林比较Warfarin Comparedwith Aspirin100%-50%50%-100%0Warfarin BetterWarfarin WorseAFASAK I(1)AFASAK II(2)EAFT(9)PATAF(15)SPAF II(4)All Trials(n=5)Relative Risk Reduction(95%CI)(2019 ACC/AHA/ESC 房颤处理指南综合房颤处理指南综合-5000例例,-200例卒中，随访例卒中，随访2年年)
