1、Capillaries are made only of endotheliumEndotheliumNeutrophilMonocyteIL-6IL-1TNF-IL-6Activated Protein CInactivationInactivationInactivationPrevention of activationActivated Protein CInflammatory Responseto InfectionThrombotic Responseto InfectionFibrinolytic Responseto InfectionTAFIPAI-1Suppressedf
2、ibrinolysisActivatedProtein CReductionof RollingInhibitionInhibitionActivated Protein CFactor VIIIaTissue FactorCOAGULATION CASCADEFactor VaTHROMBINFibrinFibrin clotTissue FactorOrganismsPrimaryHemostasisBleedingTime;Aggregometry;ClotRetractionPLTC;BoneMarrowBleedingTime;TourniquetTestQualityQuantit
3、yPlateletsBloodVesselsFibrinolysisD-Dimer;FDPSecondaryHemostasisCoagulationFactorsACT;PT;APTT;TCT;Factor Assays;Fibrinogen;InhibitorScreen导致血栓的导致血栓的各种因素各种因素血管壁受损血管壁受损血流改变（主血流改变（主要是血流缓慢要是血流缓慢、涡流）、涡流）血液凝固异常血液凝固异常 毛细血管抵抗力试验（TourniquetTest,CRT）原理 对毛细血管壁施加压力，观察血管壁、血管内皮、血小板等综合止血作用。方法 束臂法 参考值 男性5 女性和儿童20 临床意义 毛细血管抵抗力降低（即脆性增加）见于：Plt减少如ITP、AA Plt功能异常原发或继发血小板减少或增多如血小板无力症 血管性病变如血管性血友病、坏血病等血管通透性增加的疾病。Timer is started upon incisionBT=Time to complete cessation of free blood flow
