1、冠状动脉血流储备的临床应用Rest基础状态140gkg-1min-1CFV冠脉血流速度冠脉血流速度3minCFV冠脉血流速度冠脉血流速度Rest基础状态50 g75 g100 g140 g1min1min1min3min020406080100B5075100140基础状态及腺苷注入剂量心率(次/分)、血压(mmHg)及平均血流速度(c m/s)HRMBPAPV注入腺苷后所致的心率、血压及平均血流速度的变化 01020304050607080baseline50g75g100g140gAdenosine dose(g/kg/min)APV(cm/s)APVb的TTDE与ICD测值的相关性分析y
2、=0.59x+6.44 r=0.89,n=106,p0.00105101520253035400102030405060APVb-ICD(cm/s)APVb-TTDE(cm/s)APVh的TTDE与ICD测值的相关性分析y=0.46x+23.98 r=0.76,n=106,p0.001020406004080120APVh-ICD(cm/s)APVh-TTDE(cm/s)CFVR的TTDE与ICD测值的相关性分析y=0.76x+0.61 r=0.83,n=106,p0.001012345012345CFVR-ICDCFVR-TTDE 冠状动脉狭窄冠状动脉狭窄Coronary Stenosis
3、H Lambertz et al.J Am Soc Echo 1999,12:186-95Coronary Stenoses冠状动脉狭窄CFVR=1.3CFVR=2.8CFVR=3.3冠状动脉介入治疗的效果并追踪随访以ICD探测的CFVR2.5为判断CFVR受损的切断点，TTDE的敏感性和特异性分别为92.31%和88.46%正常冠脉-微循环受损Microvascular Dysfunction 肥厚型心肌病00.511.522.533.5CFVRHCMControlP0.00105101520253035404550APVBaselineHyperemiaHNp0.005NS00.511.522.533.5CFVRHNp0.0001CFVR减低
